The markets closed lower with the Dow falling 53 points to 22,296 after North Korea claimed that the U.S. declared war against the reclusive regime. Nasdaq tumbled 56 points to 6,370.

On the upside

Daily Stock Tracker noted that AcelRx Pharmaceuticals' (Nasdaq: ACRX) stock price has climbed 11.67% over the past month and 55.81 over the past three months.

Celldex Therapeutix (Nasdaq: CLDX) will present at the Cantor Fitzgerald Global Healthcare Conference tomorrow.

Mubadala Petroleum extended its drilling contract with an Atwood Oceanics (NYSE: ATW) subsidiary for four months..

On the downside

Concerns about potential tariffs on solar module imports weighed down shares of residential solar installer Vivint Solar (NYSE: VSLR).

Investors locked in profits on Bright Scholar Education Holdings (NYSE: BEDU).

Shares of Quest Diagnostics (NYSE: DGX) plunged after the Centers for Medicare and Medicaid Services proposed cuts to the reimbursement rates for lab tests.

The broader S&P 500 fell 5 points to 2,496. Bitcoin leaped $259 to $3,927.