A cyber breach of the Securities and Exchange Commission's computer system weighed the markets down to a lower close with the Dow falling 53 points to 22,359. Nasdaq dropped 33 points to 6,422.

On the upside

IBC2017 awarded a NewBay Best of Show Award to the artificial intelligence solution to aiWARE for Xcellis from Veritone (Nasdaq: VERI) and Quantum (NYSE: QTM).

Zacks Investment Research upgraded Kindred Healthcare (NYSE: KND) from a Sell rating to a Hold rating.

Third Point Reinsurance (NYSE: TPRE) will be added to the S&P SmallCap 600 before market open on Tuesday, September 26, 2017.

On the downside

The Food and Drug Administration warned that Intercept Pharmaceuticals' (Nasdaq: ICPT) Ocalivia may cause liver damage and possible death.

Juno Therapeutics (Nasdaq: JUNO) announced a follow-on public offering of $225 million of its common stock.

Investors locked in profits on Atwood Oceanics (NYSE: ATW).

In the broad market, declining issues outpaced advancers by a margin of 4 to 3 on the NYSE and by 5 to 4 on Nasdaq. The broader S&P 500 fell 7 points to 2,500. Bitcoin crashed $286 to $3,652.