Uncertainty about interest rates sent the markets into a tailspin during the midday with the Dow crashing 291 points to 16,083. Nasdaq plummeted 56 points to 4,676.

On the upside

RBC Capital Markets upgraded Rayonier Advanced Materials (NYSE: RYAM) from a Sector Perform rating to an Outperform rating.
 
Jefferies slashed its price target on Joy Global (Nasdaq: JOY) from $34 to $20 but the stock price rose.

Shares of Trevana (Nasdaq: TRVN) climbed again.

On the downside

Falling copper prices weighed down shares of Teck Resources (NYSE: TCK).
 
Stereotaxis (Nasdaq: STXS) will conduct a registered offering of subscription warrants.

Shares of BP (NYSE: BP) fell as crude oil price slipped.

In the broad market, declining issues outpaced advancers by a margin of more than 7 to 2 on the NYSE and by more than 2 to 1 on Nasdaq. The broader S&P 500 plunged 32 points to 1,918. Bitcoin rose $2 to $228.