Silo Pharma (NASDAQ: SILO) is a developmental stage biopharmaceutical company focused on developing novel formulations and drug delivery systems for traditional therapeutics and psychedelic treatments. The company today announced positive data in the final validation report from the recent pharmacokinetic (“PK”) study of SPC-15, an intranasal prophylactic treatment for anxiety and post-traumatic stress disorder (“PTSD”). Conducted as part of non-GLP small animal dose-ranging study of SPC-15 completed in February 2024, the activity of SPC-15 in the subjects of the PK study was evaluated over a 7-day repeat intranasal dose, including the processes of absorption, distribution and excretion. Time to peak drug concentration (“T max”) occurred between 0.5 and 2 hours following intranasal administration compared to 2 hours following oral gavage administration. “Our evaluation of the PK profile for SPC-15 indicates effective and consistent exposure from intranasal administration of the drug,” said Silo CEO Eric Weisblum. “We believe these study results will be substantially replicated in humans.”

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About Silo Pharma Inc.

Silo Pharma is a developmental-stage biopharmaceutical company developing novel therapeutics that address underserved conditions including stress-induced psychiatric disorders, chronic pain conditions and central nervous system (“CNS”) diseases. Silo focuses on developing traditional therapies and psychedelic treatments in novel formulations and drug delivery systems. The company’s lead program, SPC-15, is an intranasal treatment targeting PTSD and stress-induced anxiety disorders. SP-26 is a time-release ketamine-loaded implant for fibromyalgia and chronic pain relief. Silo’s two preclinical programs are SPC-14, an intranasal compound for the treatment of Alzheimer’s disease, and SPU-16, a CNS-homing peptide targeting multiple sclerosis (“MS”). Silo’s research and development programs are conducted through collaborations with Columbia University and the University of Maryland, Baltimore. For more information about the company, visit www.SiloPharma.com.

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