Cybin (NYSE American: CYBN) (NEO: CYBN) shared promising 12-month efficacy data from its Phase 2 study of CYB003, a proprietary deuterated psilocin treatment for major depressive disorder (“MDD”). Participants receiving two 16 mg doses of CYB003, three weeks apart, achieved a 100% response rate and 71% remission rate at the 12-month mark, with an average reduction of 23 points in MADRS scores. The study highlighted CYB003’s potential as a safe, effective, and durable alternative to traditional treatments, offering relief with just two doses per treatment cycle. With its Phase 3 pivotal program underway, Cybin is advancing toward regulatory approval and commercialization to address significant unmet needs in MDD care.

To view the full press release, visit https://ibn.fm/jl1E5

About Cybin Inc.

Cybin is a clinical-stage biopharmaceutical company on a mission to create safe and effective psychedelic-based therapeutics to address the large unmet need for new and innovative treatment options for people who suffer from mental health conditions. Cybin’s goal of revolutionizing mental healthcare is supported by a network of world-class partners and internationally recognized scientists aimed at progressing proprietary drug discovery platforms, innovative drug delivery systems, and novel formulation approaches and treatment regimens. The company is currently developing CYB003, a proprietary deuterated psilocybin analog for the treatment of major depressive disorder and CYB004, a proprietary deuterated DMT molecule for generalized anxiety disorder and has a research pipeline of investigational psychedelic-based compounds. Headquartered in Canada and founded in 2019, Cybin is operational in Canada, the United States, the United Kingdom, the Netherlands and Ireland. For company updates and to learn more about Cybin, visit www.Cybin.com.

NOTE TO INVESTORS: The latest news and updates relating to CYBN are available in the company’s newsroom at https://ibn.fm/CYBN

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