Silo Pharma (NASDAQ: SILO) announced encouraging preclinical study results for SPC-15, a novel dual-target therapy combining a serotonin 5-HT4 receptor agonist and an NMDA receptor antagonist. The treatment demonstrated superior efficacy in reducing stress-induced behaviors in animal models compared to single-agent therapies, highlighting its potential for managing major depressive disorder and other severe stress-related conditions. CEO Eric Weisblum emphasized the promising implications of SPC-15 as an intranasal prophylactic treatment for PTSD, with plans for an IND submission to initiate human trials. Developed in collaboration with Columbia University, SPC-15 may qualify for the FDA’s expedited 505(b)(2) approval pathway.

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About Silo Pharma Inc.

Silo Pharma is a developmental-stage biopharmaceutical company developing novel therapeutics that address underserved conditions including stress-induced psychiatric disorders, chronic pain conditions and central nervous system (“CNS”) diseases. Silo focuses on developing traditional therapies and psychedelic treatments in novel formulations and drug-delivery systems. The company’s lead program, SPC-15, is an intranasal treatment targeting post-traumatic stress disorder (“PTSD”) and stress-induced anxiety disorders. SP-26 is a time-release, ketamine-loaded implant for fibromyalgia and chronic pain relief. Silo’s two preclinical programs are SPC-14, an intranasal compound for the treatment of Alzheimer’s disease, and SPU-16, a CNS-homing peptide targeting multiple sclerosis (“MS”). Silo’s research and development programs are conducted through collaborations with universities and independent laboratories. For more information about the company, visit www.SiloPharma.com .

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