Calidi Biotherapeutics (NYSE American: CLDI) presented data at the International Oncolytic Virotherapy Conference and the Society for Immunotherapy of Cancer Annual Meeting highlighting its RTNova systemic virotherapy technology. This innovative platform leverages a tumor-selective vaccinia virus enhanced with extracellular enveloped viruses (“EEVs”) to overcome challenges like immune clearance and limited targeting in systemic virotherapy. RTNova demonstrated potential to target and kill metastatic tumor sites across multiple oncology indications, including metastatic lung cancer, while transforming tumor microenvironments and delivering therapeutic payloads. These findings position RTNova as a groundbreaking approach for addressing advanced metastatic diseases, supporting Calidi’s mission to develop multi-modal, off-the-shelf virotherapies for a broader patient population.

To view the full press release, visit: https://ibn.fm/REQoD

About Calidi Biotherapeutics

Calidi Biotherapeutics specializes in proprietary technology that empowers the immune system to combat cancer. The company’s novel stem cell-based platforms utilize potent allogeneic stem cells capable of carrying payloads of oncolytic viruses for use in multiple oncology indications, including high-grade gliomas and solid tumors. Calidi’s clinical stage off-the-shelf, universal cell-based delivery platforms are designed to protect, amplify, and potentiate oncolytic viruses leading to enhanced efficacy and improved patient safety. Calidi’s preclinical off-the-shelf enveloped virotherapies are designed to target disseminated solid tumors. This dual approach can potentially treat, or even prevent, metastatic disease. Calidi Biotherapeutics is headquartered in San Diego, California. For more information, please visit www.calidibio.com

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