IGC Pharma (NYSE American: IGC), a clinical-stage pharmaceutical company, is sharing details regarding its drug candidate TGR-63, which targets amyloid-beta plaque and has potential to improve Alzheimer’s disease treatment in a significant manner. According to the announcement, preclinical trial data shows TGRr-63 reduces plaque in Alzheimer’s. The company observed that “a key pathological marker of Alzheimer’s disease is the formation of abnormal clusters of protein fragments called amyloid-beta (‘Aβ’) that deposit as Aβ plaque between neurons in the brain and contribute to cognitive decline and memory loss.” The U.S. Food and Drug Administration (“FDA”) has approved two drugs, Aducanumab and Lecanemab, which are designed clear Aβ plaque from the brain as part of a therapeutic approach focused on modifying the course of the disease. IGC’s TGR-63 is a patent-pending molecule designed to disrupt the structure of Aβ plaque aggregation by disrupting intermolecular interactions and destabilizing their assembly. “The FDA’s recent approval of innovative drugs like Aducanumab and Lecanemab underscores the profound impact of targeting plaque formation in Alzheimer’s,” said IGC Pharma CEO Ram Mukunda in the press release. “TGR-63 aligns with this visionary approach, rekindling hope, and tangible progress in our fight against this neurodegenerative disease. TGR-63 is a potential Alzheimer’s drug in the standard preclinical methodologies, first in Alzheimer’s cell lines, then in amyloid animal models, and finally with its ability to penetrate the blood-brain barrier.”

To view the full press release, visit https://ibn.fm/j9rJN

About IGC Pharma

IGC Pharma is pursuing innovative solutions to fight Alzheimer’s disease and related challenges. The company’s portfolio comprises five assets, all with a singular mission: to transform the landscape of Alzheimer’s treatment. IGC-AD1 and LMP target neuroinflammation, Aβ plaques and neurofibrillary tangles. IGC-AD1 is currently in a phase 2b clinical trial for agitation in dementia due to Alzheimer’s. TGR-63 targets Aβ plaque to disrupt the progression of Alzheimer’s disease. IGC-M3 targets the inhibition of Aβ plaque aggregation with the potential to create a profound impact on early-stage Alzheimer’s. IGC-1C targets tau and neurofibrillary tangles as a forward-thinking approach to Alzheimer’s therapy. In parallel, IGC Pharma is at the forefront of generative AI development, with projects including clinical trials, early detection of Alzheimer’s and drug interactions with cannabinoids. For more information, visit the company’s website at www.IGCInc.us.

NOTE TO INVESTORS: The latest news and updates relating to IGC are available in the company’s newsroom at https://ibn.fm/IGC

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