Vistagen Therapeutics (NASDAQ: VTGN), a late clinical-stage biopharmaceutical company aiming to transform the treatment landscape for individuals living with anxiety, depression and other central nervous system (“CNS”) disorders, has received a Notice of Allowance from the Canadian Intellectual Property Office (“CIPO”) for a patent related to AV-101. AV-101 is the company’s oral prodrug antagonist at the NMDAR (N-methyl-D-aspartate receptor) glycine site designed for reduction of dyskinesia, or sudden uncontrolled movements, induced by the administration of levodopa (“L-Dopa”), which is commonly prescribed for treatment of Parkinson’s disease (“PD”). According to the announcement, published preclinical data indicates that AV-101 reduces levodopa-induced dyskinesias without adverse side effects and without affecting the timing, extent or duration of the therapeutic benefits of L-Dopa. Vistagen has already received similar patents for AV-101 from the U.S. Patent and Trademark Office (“USPTO”) and similar patents have been granted or are pending in several additional major pharmaceutical markets.

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About Vistagen Therapeutics Inc.

Vistagen Therapeutics is a late clinical-stage biopharmaceutical company aiming to transform the treatment landscape for individuals living with anxiety, depression and other CNS disorders. The company is advancing therapeutics with the potential to be faster acting and with fewer side effects and safety concerns than treatments that are currently available for treatment of anxiety, depression and multiple CNS disorders. Vistagen’s pipeline includes six clinical-stage product candidates, including fasedienol (“PH94B”), itruvone (“PH10”), PH15, PH80 and PH284, each an investigational agent belonging to a new class of drugs known as pherines, as well as AV-101, which is an oral antagonist of the N-methyl-D-aspartate receptor (“NMDAR”). Pherines, which are administered as low-dose nasal sprays, are designed with a novel rapid-onset mechanism of action that activates chemosensory neurons in the nasal cavity and can beneficially impact key neural circuits in the brain without systemic uptake or direct activity on CNS neurons in the brain. Vistagen is passionate about transforming mental health care and redefining what is possible in the treatment of anxiety, depression and several other CNS disorders. For more information about the company, please visit www.Vistagen.com.

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