African trypanosomiasis is a progressive illness that affects both humans and animals. The illness is caused by a parasite known as Trypanosoma brucei (T. brucei). In the course of infection, T. brucei colonizes adipose tissue and rapidly grows in the host. This, researchers theorize, may cause weight loss because it primarily affects the biggest visceral adipose tissue depot, the gonadal AT.

The infection works by offsetting the balance between anabolism and catabolism, which takes place in the adipocytes’ lipid droplets. An increase in lipid catabolism then…

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