BiondVax Pharmaceuticals (NASDAQ: BVXV), a biotech company focused on developing, manufacturing and commercializing innovative immunotherapeutic products primarily for the treatment of infectious and autoimmune diseases, has published a letter from CEO Amir Reichman. The letter provides an overview of 2022 accomplishments, including the company’s successful preclinical trial results of the inhaled COVID-19 NanoAb therapy, along with a report of recent financing activities to support 2023 objectives. Highlights of the letter include the signing a series of collaboration agreements with the Max Planck Institute for Multidisciplinary Sciences (“MPI”) and the University Medical Center Göttingen, Germany (“UMG”) for the development of NanoAbs addressing diseases with large unmet medical needs that also have commercial potential such as asthma, psoriasis, psoriatic arthritis, and macular degeneration, in addition to the COVID-19 program signed in Q4 2021. BiondVax also signed a definitive amendment to its existing loan agreement with the European Investment Bank that extends the maturity of its €24 million loan until Dec. 31, 2027, and initiated discussions with potential clients interested in hiring the company as a contract development and manufacturing organization. In addition, the company reported the successful first readout results in the preclinical in vivo study of its innovative inhaled COVID-19 NanoAb therapy. “BiondVax’s 2022 achievements leave me incredibly optimistic about BiondVax’s growth potential and ability to deliver value to our stakeholders,” stated BiondVax Pharmaceuticals CEO Amir Reichman in the letter. “With funding in place to continue development, our plans include executing several steps required to bring our inhaled COVID-19 NanoAb therapy into a first-in-human phase 1/2a clinical trial by the end of 2023. These steps include toxicology studies and GMP manufacturing of the NanoAb. We also intend to exercise our option to obtain an exclusive license at preagreed financial terms to anti-IL-17 NanoAbs from our partners in Germany, scale up in-house NanoAb manufacturing, conduct an in vitro proof-of-concept study and potentially also a preclinical trial of the IL-17 NanoAb as a therapy for psoriasis. . . . I believe we have set the stage in 2022 for a highly successful 2023. The BiondVax team, in collaboration with our scientific partners from MPI and UMG, has worked exceedingly hard to develop the company into a global leader in NanoAb technology.”

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About BiondVax Pharmaceuticals Ltd.

BiondVax Pharmaceuticals, a biotechnology company focused on developing, manufacturing and commercializing innovative immunotherapeutic products primarily for the treatment of infectious and autoimmune diseases. Since its inception, the company has executed eight clinical trials including a seven-country, 12,400-participant, phase 3 trial of its prior vaccine candidate; the company has also built a state-of-the-art manufacturing facility for biopharmaceutical products. With highly experienced pharmaceutical industry leadership, BiondVax is aiming to develop a pipeline of diversified and commercially viable products and platforms beginning with an innovative nonosized antibody (“NanoAb”) pipeline. For more information about the company, please visit www.BiondVax.com

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