VistaGen Therapeutics (NASDAQ: VTGN), a late clinical-stage biopharmaceutical company aiming to transform the treatment landscape for individuals living with anxiety, depression and other central nervous system (“CNS”) disorders, has published findings of a preclinical study of its oral NMDA receptor glycine site antagonist, AV-101. The positive findings evaluated the effects of AV-101 in a widely used MPTP nonhuman primate model for reproducing motor complications of Parkinson’s disease (“PD”), including dyskinesia, or sudden uncontrolled movements, observed in PD patients treated with levodopa (“L-Dopa”). The preclinical data indicate a significant reduction of levodopa-induced dyskinesia by AV-101, while maintaining antiparkinsonian activity of levodopa. Vistagen is working to show that AV-101, alone or in combination with FDA-approved oral probenecid, has potential to become an oral treatment alternative for certain CNS disorders involving the NMDAR. The findings from the preclinical study were published in “Cells,” an international, peer-reviewed journal. “While L-Dopa remains the most effective pharmacotherapy for Parkinson’s disease, the occurrence of LID is difficult to manage and drastically interferes with Parkinson’s patients’ quality of life,” said Vistagen CEO Shawn Singh in the press release. “This preclinical study showed that AV-101 reduced LID with no adverse effects of treatment. Dr. Di Paolo has been at the forefront of research in neuropharmacology and treatments for Parkinson’s disease for decades. Her preclinical data from this study are compelling and highlight AV-101’s potential to improve the treatment paradigm for LID associated with Parkinson’s therapy by reducing LID while still maintaining the antiparkinsonian activity of L-Dopa.”

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About VistaGen Therapeutics Inc.

VistaGen is a late clinical-stage CNS-focused biopharmaceutical aiming to transform the treatment landscape for individuals living with anxiety, depression and other CNS disorders. The company is advancing therapeutics with the potential to be faster acting and with fewer side effects and safety concerns than those that are currently available. Vistagen’s clinical-stage candidates are targeting multiple forms of anxiety and depression. PH94B and PH10 belong to a new class of drugs known as pherines, which are odorless and tasteless investigational neuroactive steroids designed with a novel rapid-onset mechanism of action that activates chemosensory neurons in the nasal passages and can impact the olfactory-amygdala neural circuits without systemic uptake or direct activity on CNS neurons in the brain. Vistagen is passionate about transforming mental health care and redefining what is possible in the treatment of anxiety and depression — one mind at a time. For more information about the company, please visit www.VistaGen.com.

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