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-Many people routinely reach for over-the-counter pain medications for immediate pain relief, especially during cold and flu season. Individuals also may reach for these medications to manage symptoms related to COVID-19. However, most people are unaware that some over-the-counter pain relievers can raise blood pressure. Only six out of 10 (63 percent) of adults with high blood pressure say they check with their doctors before choosing an over-the-counter (OTC) pain reliever, according to a recent survey commissioned by the American Heart Association.