• The scientific poster highlights the role of pro-inflammatory macrophages and monocytes in reducing regulatory T cell (Treg) immunomodulatory suppressive function and the anti-inflammatory effect of Treg-enhancing therapies combined with drugs that suppress M1 pro-inflammatory activated monocytes and macrophages in ALS;
• COYA 302 is a dual-mechanism investigational biologic combination comprised of proprietary low dose interleukin-2 (LD IL-2) and CTLA-4 Ig and is being investigated for the treatment of ALS.

Coya Therapeutics, Inc. (Nasdaq: COYA) (“Coya” or the “Company”), a clinical-stage biotechnology company developing biologics and cell therapies intended to enhance the function of Tregs, today announced the acceptance and presentation of a poster at the 22^nd Annual Northeast ALS (NEALS) Consortium Meeting on October 4^th, 2023.

The experimental data generated in samples from ALS patients highlight the role of M1 pro-inflammatory monocytes and macrophages in reducing the immunomodulatory anti-inflammatory function of Tregs. Also documented is the significant effect of combination therapies that both enhance Treg function and suppress M1 activated macrophages and monocytes resulting in the reduction of pro-inflammatory cytokines known to be involved in inflammatory response and tissue damage. Results of this study reinforce the potential of COYA 302 that may address the complex pathophysiology and multiple pathways involved in the progression and severity of ALS.

Fred Grossman, President and Chief Medical Officer said, “The data being presented provides additional mechanistic rationale and support for combination therapies targeting multiple immune pathways in ALS.”

Details of the poster presentation at the NEALS Annual Meeting are as follows:

Date: October 5^th, 2023

Title: Monocytes/Macrophages Impair Regulatory T-Lymphocyte Suppressive Function

Poster Number: 132

For Conference Information visit: https://neals.org/als-researchers/annual-neals-meeting

About Coya Therapeutics, Inc.

Headquartered in Houston, TX, Coya Therapeutics, Inc. (Nasdaq: COYA) is a clinical-stage biotechnology company developing proprietary treatments focused on the biology and potential therapeutic advantages of regulatory T cells (“Tregs”) to target systemic inflammation and neuroinflammation. Dysfunctional Tregs underlie numerous conditions including neurodegenerative, metabolic, and autoimmune diseases, and this cellular dysfunction may lead to a sustained inflammation and oxidative stress resulting in lack of homeostasis of the immune system. Coya’s investigational product candidate pipeline leverages multiple therapeutic modalities aimed at restoring the anti-inflammatory and immunomodulatory functions of Tregs. Coya’s lead therapeutic programs includes Treg-enhancing biologics (COYA 300 Series product candidates) COYA 301 and COYA 302, which are intended to enhance Treg function and expand Treg numbers. COYA 301 is a proprietary investigational recombinant human low dose IL-2 biologic for subcutaneous administration intended to enhance Treg function and expand Treg numbers in vivo, and COYA 302 is a dual-mechanism investigational biologic combination comprised of proprietary low dose IL-2 and CTLA-4 Ig. The low dose IL-2 is intended to enhance anti-inflammatory regulatory T cell function and numbers while the fusion protein CTLA-4 Ig is intended to suppress pro-inflammatory cell function. These two mechanisms may be additive or synergistic in suppressing inflammation. For more information about Coya, please visit www.coyatherapeutics.com

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