As Filed with the Securities and Exchange Commission on March 13, 2003 Registration No. 333-103601 ================================================================================ SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 AMENDMENT NO. 2 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 --------------------- THE MEDICINES COMPANY (Exact Name of Registrant as Specified in Its Charter) DELAWARE 04-3324394 (State of Incorporation) (I.R.S. Employer Identification Number) FIVE SYLVAN WAY, SUITE 200 PARSIPPANY, NEW JERSEY 07054 (973) 656-1616 (Address, Including Zip Code, and Telephone Number, Including Area Code, of Registrant's Principal Executive Offices) --------------------- CLIVE A. MEANWELL EXECUTIVE CHAIRMAN THE MEDICINES COMPANY FIVE SYLVAN WAY, SUITE 200 PARSIPPANY, NEW JERSEY 07054 (973) 656-1616 (Name, Address, Including Zip Code, And Telephone Number, Including Area Code, of Agent For Service) --------------------- COPIES TO: STUART M. FALBER, ESQ. PATRICK O'BRIEN, ESQ. HALE AND DORR LLP ROPES & GRAY 60 STATE STREET ONE INTERNATIONAL PLACE BOSTON, MASSACHUSETTS 02109 BOSTON, MASSACHUSETTS 02110 (617) 526-6000 (617) 951-7000 --------------------- Approximate date of commencement of proposed sale to the public: As soon as practicable after this registration statement becomes effective. If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. [ ] If any of the securities being registered on this form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. [ ] If this form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [ ] If this form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [ ] If delivery of the prospectus is expected to be made pursuant to Rule 434, please check the following box. [ ] THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A), SHALL DETERMINE. ================================================================================ EXPLANATORY NOTE This Amendment No. 2 to the registration statement on Form S-3 (File No. 333-103601) of The Medicines Company is being filed solely for purposes of filing Exhibit 1.1 to the registration statement and amending Item 16 of Part II of the registration statement accordingly. PART II INFORMATION NOT REQUIRED IN PROSPECTUS Item 16. Exhibits (a) Number Description ------ ----------- 1.1 Form of Underwriting Agreement 3.1* Third Amended and Restated Certificate of Incorporation of the registrant 3.2* Amended and Restated By-laws of the registrant 5.1** Opinion of Hale and Dorr LLP 23.1** Consent of Ernst & Young LLP, Independent Auditors 23.2** Consent of Hale and Dorr LLP (included in Exhibit 5.1) 24.1** Powers of Attorney * Incorporated by reference from the exhibits to the registration statement on Form S-1 (registration no. 333-37404). ** Previously filed. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this Amendment No. 2 to the registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Parsippany, state of New Jersey, on March 12, 2003. THE MEDICINES COMPANY By: /s/ Steven H. Koehler ------------------------------- Steven H. Koehler Vice President and Chief Financial Officer Pursuant to the requirements of the Securities Act of 1933, as amended, this Amendment No. 2 to the registration statement has been signed by the following persons in the capacities indicated on March 12, 2003: SIGNATURE TITLE(S) --------- -------- * Executive Chairman and Chairman of the Board of --------------------------------------------------------- Directors (Principal Executive Officer) Clive A. Meanwell * Chief Executive Officer, President and Director --------------------------------------------------------- (Principal Executive Officer) David M. Stack /s/ Steven H. Koehler Chief Financial Officer (Principal Financial and --------------------------------------------------------- Accounting Officer) Steven H. Koehler * Director --------------------------------------------------------- Leonard Bell * Director --------------------------------------------------------- Stewart J. Hen * Director --------------------------------------------------------- M. Fazle Husain * Director --------------------------------------------------------- T. Scott Johnson * Director --------------------------------------------------------- Armin M. Kessler * Director --------------------------------------------------------- Nicholas J. Lowcock * Director --------------------------------------------------------- James E. Thomas *By: /s/ Steven H. Koehler ---------------------- Steven H. Koehler Attorney-in-fact EXHIBIT INDEX NUMBER DESCRIPTION ------- ----------- 1.1 Form of Underwriting Agreement 3.1* Third Amended and Restated Certificate of Incorporation of the registrant 3.2* Amended and Restated By-laws of the registrant 5.1** Opinion of Hale and Dorr LLP 23.1** Consent of Ernst & Young LLP, Independent Auditors 23.2** Consent of Hale and Dorr LLP (included in Exhibit 5.1) 24.1** Powers of Attorney ---------- * Incorporated by reference from the exhibits to the registration statement on Form S-1 (registration no. 333-37404). ** Previously filed.