Filed by Charles River Laboratories International, Inc.
pursuant to Rule 14a-12
of the Securities Exchange Act of 1934
Subject Company: Charles River Laboratories International, Inc.
(Commission File No.: 001-15943)

Bank of America Merrill Lynch Health Care Conference

Charles River and WuXi PharmaTech: The First Global Early-Stage CRO

Thomas F. Ackerman
Executive Vice President and CFO
May 12, 2010

Charles River
[C] 2010 Charles River Laboratories International, Inc.



Safe Harbor Statement

This document includes "forward-looking statements" within the meaning of the
Private Securities Litigation Reform Act of 1995. Forward-looking statements may
be identified by the use of words such as "anticipate," "believe," "expect,"
"estimate," "plan," "outlook," and "project" and other similar expressions that
predict or indicate future events or trends or that are not statements of
historical matters. These statements are based on current expectations and
beliefs of Charles River Laboratories ("Charles River") and WuXi PharmaTech
(Cayman) Inc ("WuXi"), and involve a number of risks and uncertainties that
could cause actual results to differ materially from those stated or implied by
the forward-looking statements. Those risks and uncertainties include, but are
not limited to: 1) the possibility that the companies may be unable to obtain
stockholder or regulatory approvals required for the combination; 2) problems
may arise in successfully integrating the businesses of the two companies
(including retention of key WuXi executives); 3) the acquisition may involve
unexpected costs; 4) the combined company may be unable to achieve cost and
revenue synergies; 5) the businesses may suffer as a result of uncertainty
surrounding the acquisition; and 6) the industry may be subject to future
regulatory or legislative actions and other risks that are described in
Securities and Exchange Commission ("SEC") reports filed or furnished by Charles
River and WuXi.

In addition, these statements include statements regarding the projected 2010
financial performance of WuXI, the availability of funding for our customers and
the impact of economic and market conditions on them generally, the anticipated
strength of our balance sheet, the effects of our 2009 and 2010 cost-saving
actions and other actions designed to manage expenses, operating costs and
capital spending, and to streamline efficiency, and the ability of the Company
to withstand the current market conditions. Forward-looking statements are based
on Charles River's current expectations and beliefs, and involve a number of
risks and uncertainties that are difficult to predict and that could cause
actual results to differ materially from those stated or implied by the
forward-looking statements. Those risks and uncertainties include, but are not
limited to: the ability to successfully integrate the businesses we acquire; the
ability to successfully develop and commercialize SPC's technology platform; a
decrease in research and development spending, a decrease in the level of
outsourced services, or other cost reduction actions by our customers; the
ability to convert backlog to sales; special interest groups; contaminations;
industry trends; new displacement technologies; USDA and FDA regulations;
changes in law; continued availability of products and supplies; loss of key
personnel; interest rate and foreign currency exchange rate fluctuations;
changes in tax regulation and laws; changes in generally accepted accounting
principles; and any changes in business, political, or economic conditions due
to the threat of future terrorist activity in the U.S. and other parts of the
world, and related U.S. military action overseas. A further description of these
risks, uncertainties, and other matters can be found in the Risk Factors
detailed in Charles River's Annual Report on Form 10-K as filed on February 19,
2010, as well as other filings we make with the SEC.

Because forward-looking statements involve risks and uncertainties, actual
results and events may differ materially from results and events currently
expected by Charles River and WuXi. Charles River and WuXi assume no obligation
and expressly disclaim any duty to update information contained in this filing
except as required by law.




Regulation G

This presentation includes discussion of non-GAAP financial measures with
respect to Charles River and also with respect to WuXi included in WuXi's
first-quarter 2010 earnings release filed on Form 6-K with the SEC on May 11,
2010. We believe that the inclusion of these non-GAAP financial measures
provides useful information to allow investors to gain a meaningful
understanding of our core operating results and future prospects, without the
effect of one-time charges, consistent with the manner in which management
measures and forecasts the Company's performance. The non-GAAP financial
measures included in this presentation are not meant to be considered superior
to or a substitute for results of operations prepared in accordance with GAAP.
The company intends to continue to assess the potential value of reporting
non-GAAP results consistent with applicable rules and regulations. In accordance
with Regulation G, you can find the comparable GAAP measures and reconciliations
to those GAAP measures on our website at, or with respect to WuXI,
in WuXi's current report on Form 6-K filed with the SEC on May 11, 2010,
available at the SEC's website,

Additional Information

This document may be deemed to be solicitation material in respect of the
proposed combination of Charles River and WuXi. In connection with the proposed
transaction, Charles River will file a preliminary proxy statement and a
definitive proxy statement with the SEC. The information contained in the
preliminary filing will not be complete and may be changed. Before making any
voting or investment decisions, investors and security holders are urged to read
the definitive proxy statement when it becomes available and any other relevant
documents filed with the SEC because they will contain important information.
The definitive proxy statement will be mailed to the shareholders of Charles
River seeking their approval of the proposed transaction. Charles River's
shareholders will also be able to obtain a copy of the definitive proxy
statement free of charge by directing a request to: Charles River Laboratories,
251 Ballardvale Street, Wilmington, MA 01887, Attention: General Counsel. In
addition, the preliminary proxy statement and definitive proxy statement will be
available free of charge at the SEC's website, or shareholders may
access copies of the documentation filed with the SEC by Charles River and on
Charles River's website at

Charles River and its directors and executive officers and other members of
management and employees may be deemed to be participants in the solicitation of
proxies in respect of the proposed transaction. Information regarding Charles
River's directors and executive officers is available in Charles River's proxy
statement for its 2010 annual meeting of shareholders, which was filed with the
SEC on March 30, 2010. Information regarding the persons who may, under the
rules of the SEC, be considered participants in the solicitation of Charles
River shareholders in connection with the proposed transaction will be set forth
in the preliminary proxy statement when it is filed with the SEC.

This document does not constitute an offer of any securities for sale or a
solicitation of an offer to buy any securities. The Charles River shares to be
issued in the proposed transaction have not been and will not be registered
under the Securities Act of 1933, as amended (the "Securities Act"), and may not
be offered or sold in the United States absent registration or an applicable
exemption from registration requirements. Charles River intends to issue such
Charles River shares pursuant to the exemption from registration set forth in
Section 3(a)(10) of the Securities Act.

Charles River



The New Charles River

[]   Charles River signed a definitive agreement to acquire WuXi PharmaTech for
     ~$1.6B (1) in cash and stock on April 26(th)

[]   The combination creates the first early-stage contract research
     organization (CRO)

     *    Offers a full range of products and services from molecule creation to
          first-in-human testing

[]   Charles River's expertise in in vivo biology combined with WuXi's expertise
     in chemistry creates a CRO capable of supporting clients' early-stage drug
     development efforts on a global basis

[]   Drives CRL shareholder value through profitable growth

(1) Based on CRL's 04/23/2010 closing stock price.

Charles River



Charles River Today

[]   A leading in vivo biology company

     *    $1.20B in net sales (FY '09)

[]   Unique portfolio of products and services focused on the research and
     development continuum for new drugs

[]   A multinational company with ~8,000 employees worldwide

     *    ~70 facilities in 16 countries

          []   Continuous expansion to support client needs

                               [GRAPHIC OMITTED]

(Source:) Based on Charles River's FY 2009 net sales.
Charles River


WuXi Today

[]   A leading chemistry company

     *    $270M in net sales (FY09)

[]   Service portfolio supports clients early with molecule creation, extending
     downstream through laboratory and manufacturing services

[]   Largest China-based CRO with ~4,200 employees worldwide

     *    One of the largest employers of chemists in the world

     *    7 facilities in China and U. S. to support clients globally

                               [GRAPHIC OMITTED]

(Source:) filed Based with on the WuXi's SEC information on 04/23/2010 as
disclosed and other in public its Form documents. 20-F


Charles River



The New CRL: Global Integrated Services

Target                              Assay        Hit/Lead
Identification/ Compound            Development/ Identification/
Validation      Synthesis           Screening    Optimization

Discovery Pharma-                        Safety     Scale-up/
and Imaging cology                       Assessment Research
Services                                            Manufacture
          Research Models and Services
Phase I   Phase 2                        Phase 3
Clinical  Clinical                       Clinical   Commercial
Trials    Trials                         Trials     Manufacture
          Bioanalytical Services/Testing

Charles River



Drives Profitable Revenue Growth

[]   WuXi provides opportunity to enhance revenue growth while expanding Charles
     River's margins

[]   Discovery and Chemistry services

     *    Fastest-growing business segment as pharmas increasingly choose to
          outsource * Significant growth opportunity for WuXi's new downstream

[]   Service biology, DMPK/ADME, formulation, process research, bioanalytical
     chemistry, manufacturing

[]   GLP safety assessment in China

     *    Expands the development and scope of GLP capabilities in China

[]   Manufacturing services

     *    Emerging opportunity for active pharmaceutical ingredients (APIs) for
          clinical trial and commercial-scale manufacturing services in China

[]   New business opportunities

     *    Drives more business upstream and downstream with existing and
          prospective clients based on unprecedented scope of early-stage

[]   Expanded portfolio drives market share gains

Charles River



The New CRL Revenue Base*

Leveraging the increasing strategic importance of China

* Based on FY 2009 combined sales.  WuXi's  information is as disclosed in its
Form 20-F filed with the SEC on 04/23/2010 and other public documents.

Charles River



The New CRL Business Segments

                          2009 Combined Sales*: $1.5B
                               [GRAPHIC OMITTED]

DS: Discovery Services
RMS: Research Models and Services
PCS: Preclinical Services

* Based on FY 2009 combined sales, with Charles River's DIS included in DS and
WuXi's U.S.-based Laboratory Services included in PCS. WuXi's information is as
disclosed in its Form 20-F filed with the SEC on 04/23/2010 and other public

Charles River



Compelling Value Proposition for Clients

[]   Larger footprint with more capabilities enables clients to partner with one
     company from chemistry to man

[]   More attractive partner for biopharmaceutical companies looking to gain
     more value from fewer service providers

[]   Enables clients to choose where to work: North America, Europe or China

     *    Charles River brand supports placement of work in China

[]   Seamless transfer of therapeutics across the early-stage continuum helps
     reduce time and cost to bring a drug to market

     *    Enables sponsors to make earlier "go/no-go" decisions

Charles River




Enhancing Client Relationships

[]   Focus on expanding existing client partnerships

     *    Enhances solid, high-level relationships in the same companies

     *    Strengthens relationships with those clients where one company is

     *    Creates new opportunities with clients where both entities currently
          have minority share

[]   Client retention driven by breadth of portfolio, high-quality science and
     exceptional service

Charles River




Very Favorable Client Response

[]   Senior management of CRL contacted top 20 major pharmaceutical and
     biotechnology clients within 24 hours of announcement

[]   Viewed the acquisition as strategic fit with CRL's in vivo business,
     offering clients the opportunity for larger relationships with CRL

     *    Clients already requesting follow-up meetings to discuss potential
          expansion of relationships upstream

[]   Value of CRL brand seen as an advantage in terms of standardizing products
     and services in China

Charles River




The New CRL Client Base

[]   Client base composed of big pharma and biotech, small and mid-tier pharma
     and biotech, academic and government clients, CROs and agricultural and
     chemical manufacturers

[]   Top 10 clients represent ~35% of combined sales

[]   No single client represents more than 6% of sales


* Based on FY 2009 combined sales. WuXi's information is as disclosed in its
Form 20-F filed with the SEC on 04/23/2010 and other public documents.

Charles River



2011 General Assumptions(1)

[]   Expect to recognize ~$20M of cost synergies

     *    Public company costs, SGandA, and refinement of operating structure

[]   ~4.5% average interest rate on new debt

     *    New debt of ~$950M

[]   Existing term loan is repaid

     *    Debt amortization begins in 4Q2010 (after close)

[]   Expect to accelerate repayment with cash flow

[]   Consolidated CRL non-GAAP tax rate expected to be ~25%-26%

[]   ~85-86M CRL shares outstanding post-close

[]   Expected to be neutral (at bottom of or below collar) to slightly accretive
     to non-GAAP EPS in 2011, and increasingly accretive thereafter

(1)  Combined financial information is presented as a supplementary non-GAAP
     financial measure, and is not intended to be superior to or a substitute
     for any financial measure prepared in accordance with GAAP. Furthermore,
     combined financial information is not equivalent to pro forma financial
     information as may be included in any proxy statement Charles River will
     file with the SEC in connection with this transaction. For example,
     combined financial information does not give effect to adjustments likely
     to be found in pro forma financial information such as increased
     amortization and depreciation. Items excluded from non-GAAP EPS consist of
     all deal-related costs including repatriation impact.

Charles River


WuXi 1Q10 Results(1)

[]   Strong Q1 net revenues increase of 36% to $80.6M

                 Non-    %[] from
($ in millions)  GAAP OI 1Q09
Reported         $20.5   57%
Share-based comp (2.3)   15%
CRL Presentation $18.2   65%

[]   Non-GAAP diluted earnings per ADS of $0.25, an increase of 26%

     *    Non-GAAP earnings exclude share-based compensation costs associated
          with FAS123R

(1) Source: WuXi 1Q10 earnings release issued on May 11, 2010, as included in
the Form 6-K filed with the SEC on May 11, 2010.

Charles River



WuXi 2010 Guidance(1)

[]   2Q10 Guidance

     *    Net revenues of $76-$78M

     *    Non-GAAP gross margin better than 1Q10

[]   Reaffirmed guidance for 2010 at the upper end of ranges

     *    Net revenues growth of 15-19% to $310-$320M

     *    Growth in non-GAAP operating income of up to 10%

[]   "Continue to expect strong financial performance throughout 2010 and

(1) Source: WuXi 1Q10 earnings release issued on May 11, 2010, as included in
the Form 6-K filed with the SEC on May 11, 2010.



Transaction Summary

Purchase price        ~$1.6B(1),including the assumption
                      of WuXi's debt and cash
Consideration         $21.25(1) total per ADS subject to collar (below)
per share                   o $11.25 in cash (~53%) plus
                            o $10.00 of CRL common stock (~47%)
                               determined by exchange ratio
Exchange Ratio        $10.00 divided by 20-day weighted average closing price
                      prior to closing subject to collar (below)
Collar                At Charles River's stock price of $37.1486 or below,
                      exchange ratio is fixed at 0.2692; at a price of $43.1726
                      or above, exchange ratio is fixed at 0.2316
Premium               28% based on  WuXi's 04/23/2010 closing price of $16.57
                      38% based on 30-day average closing price of $15.45
Expected closing      By 4Q10, subject to approval by each company's
                      shareholders and the satisfaction of customary closing
                      conditions and regulatory approvals
Ownership             Approximately 78%  Charles River/
                             22%  WuXi pro forma ownership
Tax Treatment         Taxable exchange under place U.S. tax law

(1) Based on CRL's 04/23/2010 closing stock price.




Integration Planning

[]   Integration team leaders have already met (week of 5/3)

     *    CRL: Dave Johst, EVP, Human Resources, General Counsel and CAO

     *    WX: Edward Hu, COO

[]   Forming integration sub-teams and identifying key objectives

     *    Goal: "Hit the ground running" after close




WuXi Senior Management Joins CRL

[]   Ge Li, PhD: Corporate EVP and President, Global Discovery and China

     *    Joins CRL Board, along with two additional directors chosen by WuXi

[]   Edward Hu: Corporate SVP and General Manager, Global Discovery and China

[]   Shuhui Chen, PhD: Corporate SVP and General Manager, Chemistry Services and
     Chief Scientific Officer, China

[]   Suhan Tang, PhD: Corporate VP and General Manager, Manufacturing Services

[]   Employment agreements with top four executives

     *    Each agreement has a three-year term




The New CRL: A Unique Opportunity

[]   Combines leaders in in vivo biology and chemistry

[]   Larger footprint with more capabilities enables clients to partner with one
     company from chemistry to man

[]   Supportive of global pharmas who view China as the new frontier for drug

[]   Dramatically improves both companies' ability to meet existing and future
     client needs

[]   WuXi provides opportunity to drive revenue growth while expanding Charles
     River's margins

     *    Expect to generate $20M in annual cost synergies

     *    Opportunity for meaningful revenue synergies




                    Accelerating Drug Development. Exactly.


[C] 2010 Charles River Laboratories International, Inc.