UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 13G
(Amendment No. _2_)*
UNDER THE SECURITIES EXCHANGE ACT OF 1934
THE MEDICINES COMPANY
-----------------------------------------
(Name of Issuer)
Common Stock
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(Title of Class of Securities)
58468810
-----------------------------------------
(CUSIP Number)
CUSIP No. 58468810 Page 2 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
Alta Partners
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
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(4) Citizenship or Place of Organization
California
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power -0-
Beneficially Owned
By Each Reporting (6) Shared Voting Power 837,906
Person With
(7) Sole Dispositive Power -0-
(8) Shared Dispositive Power 837,906
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
837,906 EXIT FILING --- Please see Attachment A
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(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
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(11) Percent Of Class Represented By Amount In Row (11)
2.4% EXIT FILING --- Please see Attachment A
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(12) Type Of Reporting Person
IA
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*SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No.58468810 Page 3 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
Alta BioPharma Partners, L.P.
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
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(4) Citizenship or Place of Organization
Delaware
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power -0-
Beneficially Owned
By Each Reporting (6) Shared Voting Power 837,906
Person With
(7) Sole Dispositive Power -0-
(8) Shared Dispositive Power 837,906
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
837,906 EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
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(11) Percent Of Class Represented By Amount In Row (11)
2.4% EXIT FILING --- Please see Attachment A
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(12) Type Of Reporting Person
PN
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CUSIP No. 58468810 Page 4 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
Alta BioPharma Management Partners, LLC.
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
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(4) Citizenship or Place of Organization
Delaware
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power 837,906
Beneficially Owned
By Each Reporting (6) Shared Voting Power -0-
Person With
(7) Sole Dispositive Power 837,906
(8) Shared Dispositive Power -0-
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
837,906 EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
-------------------------------------------------------------------------------------------------------------------
(11) Percent Of Class Represented By Amount In Row (11)
2.4% EXIT FILING --- Please see Attachment A
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(12) Type Of Reporting Person
CO
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CUSIP No. 58468810 Page 5 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
The Medicines Company Chase Partners (Alta Bio), LLC
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
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(4) Citizenship or Place of Organization
Delaware
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power -0-
Beneficially Owned
By Each Reporting (6) Shared Voting Power 837,906
Person With
(7) Sole Dispositive Power -0-
(8) Shared Dispositive Power 837,906
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
837,906 EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
-------------------------------------------------------------------------------------------------------------------
(11) Percent Of Class Represented By Amount In Row (11)
2.4% EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(12) Type Of Reporting Person
CO
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CUSIP No. 58468810 Page 6 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
Alta Embarcadero BioPharma Partners, LLC
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
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(4) Citizenship or Place of Organization
California
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power -0-
Beneficially Owned
By Each Reporting (6) Shared Voting Power 837,906
Person With
(7) Sole Dispositive Power -0-
(8) Shared Dispositive Power 837,906
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
837,906 EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
-------------------------------------------------------------------------------------------------------------------
(11) Percent Of Class Represented By Amount In Row (11)
2.4% EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(12) Type Of Reporting Person
CO
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CUSIP No. 58468810 Page 7 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
Alta/Chase BioPharma Management, LLC
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
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(4) Citizenship or Place of Organization
Delaware
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power -0-
Beneficially Owned
By Each Reporting (6) Shared Voting Power 837,906
Person With
(7) Sole Dispositive Power -0-
(8) Shared Dispositive Power 837,906
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
837,906 EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
-------------------------------------------------------------------------------------------------------------------
(11) Percent Of Class Represented By Amount In Row (11)
2.4% EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(12) Type Of Reporting Person
CO
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CUSIP No. 58468810 Page 8 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
Jean Deleage
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
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(4) Citizenship or Place of Organization
United States
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power 10,172
Beneficially Owned
By Each Reporting (6) Shared Voting Power 837,906
Person With
(7) Sole Dispositive Power 10,172
(8) Shared Dispositive Power 837,906
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
848,078 EXIT FILING --- Please see Attachment A
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(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
-------------------------------------------------------------------------------------------------------------------
(11) Percent Of Class Represented By Amount In Row (11)
2.4% EXIT FILING --- Please see Attachment A
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(12) Type Of Reporting Person
IN
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*SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 9 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
Garrett Gruener
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
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(4) Citizenship or Place of Organization
United States
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power 13,742
Beneficially Owned
By Each Reporting (6) Shared Voting Power 837,906
Person With
(7) Sole Dispositive Power 13,742
(8) Shared Dispositive Power 837,906
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
851,648 EXIT FILING --- Please see Attachment A
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(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
-------------------------------------------------------------------------------------------------------------------
(11) Percent Of Class Represented By Amount In Row (11)
2.5% EXIT FILING --- Please see Attachment A
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(12) Type Of Reporting Person
IN
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*SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 10 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
Daniel Janney
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
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(4) Citizenship or Place of Organization
United States
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power 18,070
Beneficially Owned
By Each Reporting (6) Shared Voting Power 837,906
Person With
(7) Sole Dispositive Power 18,070
(8) Shared Dispositive Power 837,906
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
855,976 EXIT FILING --- Please see Attachment A
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(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
-------------------------------------------------------------------------------------------------------------------
(11) Percent Of Class Represented By Amount In Row (11)
2.5% EXIT FILING --- Please see Attachment A
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(12) Type Of Reporting Person
IN
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*SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 11 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
Alix Marduel
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
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(4) Citizenship or Place of Organization
United States
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power 18,070
Beneficially Owned
By Each Reporting (6) Shared Voting Power 837,906
Person With
(7) Sole Dispositive Power 18,070
(8) Shared Dispositive Power 837,906
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
855,976 EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
-------------------------------------------------------------------------------------------------------------------
(11) Percent Of Class Represented By Amount In Row (11)
2.5% EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(12) Type Of Reporting Person
IN
-------------------------------------------------------------------------------------------------------------------
*SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 12 of 16 Pages
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(1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons
Guy Nohra
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(2) Check The Appropriate Box If A Member Of A Group (a)
(b) X
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(3) SEC Use Only
-------------------------------------------------------------------------------------------------------------------
(4) Citizenship or Place of Organization
United States
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EXIT FILING --- Please see Attachment A
Number Of Shares (5) Sole Voting Power 13,251
Beneficially Owned
By Each Reporting (6) Shared Voting Power 837,906
Person With
(7) Sole Dispositive Power 13,251
(8) Shared Dispositive Power 837,906
(9) Aggregate Amount Beneficially Owned By Each Reporting Person
851,157 EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*
-------------------------------------------------------------------------------------------------------------------
(11) Percent Of Class Represented By Amount In Row (11)
2.5% EXIT FILING --- Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
(12) Type Of Reporting Person
IN
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*SEE INSTRUCTION BEFORE FILLING OUT!
Item 1.
(a) Name of Issuer: The Medicines Company ("Issuer")
(b) Address of Issuer's Principal Executive Offices:
One Cambridge Center
Cambridge, MA 02142
Item 2.
(a) Name of Person Filing:
Alta Partners ("AP")
Alta BioPharma Partners, L.P. ("ABP")
Alta BioPharma Management Partners, LLC. ("ABMP")
Alta Embarcadero BioPharma Partners, LLC ("AEBP")
The Medicines Company Chase Partners (Alta Bio), LLC ("MCCP")
Alta/Chase BioPharma Management, LLC ("ACMP")
Jean Deleage ("JD")
Garrett Gruener ("GG")
Dan Janney ("DJ")
Alix Marduel ("AM")
Guy Nohra ("GN")
(b) Address of Principal Business Office:
One Embarcadero Center, Suite 4050
San Francisco, CA 94111
(c) Citizenship/Place of Organization:
Entities: AP California
ABP Delaware
ABMP Delaware
AEBP California
MCCP Delaware
ACMP Delaware
Individuals: JD United States
GG United States
DJ United States
AM United States
GN United States
(d) Title of Class of Securities: Common Stock
(e) CUSIP Number: 58468810
(f) Item 3. Not applicable.
Item 4. Ownership.
EXIT FILING --- Please see Attachment A
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
AP ABP ABMP AEBP MCCP ACMP
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(a) Beneficial Ownership 837,906 837,906 837,906 837,906 837,906 837,906
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(b) Percentage of Class 2.4% 2.4% 2.4% 2.4% 2.4% 2.4%
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(c) Sole Voting Power -0- -0- -0- -0- -0- -0-
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
Shared Voting Power 837,906 837,906 837,906 837,906 837,906 837,906
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
Sole Dispositive Power -0- -0- -0- -0- -0- -0-
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
Shared Dispositive Power 837,906 837,906 837,906 837,906 837,906 837,906
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
JD GG DJ AM GN
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(a) Beneficial Ownership 848,078 851,648 855,976 855,976 851,157
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(b) Percentage of Class 2.4% 2.5% 2.5% 2.5% 2.5%
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(c) Sole Voting Power 10,172 13,742 18,070 18,070 13,251
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
Shared Voting Power 837,906 837,906 837,906 837,906 837,906
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
Sole Dispositive Power 10,172 13,742 18,070 18,070 13,251
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
Shared Dispositive Power 837,906 837,906 837,906 837,906 837,906
------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
EXIT FILING
Item 5. Ownership of Five Percent or Less of a Class
Exit Filing
Item 6. Ownership of More than Five Percent on Behalf of Another Person
Not applicable.
Item 7. Identification and Classification of the Subsidiary, Which
Acquired the Security Being Reported on By the Parent Holding
Company.
Not applicable.
Item 8. Identification and Classification of Members of the Group
Not Applicable.
Item 9. Notice of Dissolution of Group
Not applicable.
Item 10. Certification
By signing below we certify that, to the best of our knowledge and belief, the
securities referred to above were acquired and are held in the ordinary course
of business and were not acquired and are not held for the purpose of or with
the effect of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.
EXHIBITS
A: Joint Filing Statement
Signature
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
Date: April 4, 2002
ALTA PARTNERS ALTA BIOPHARMA PARTNERS, L.P.
By: Alta BioPharma Management Partners, LLC
By: /s/ Jean Deleage By: /s/ Alix Marduel
----------------------------------------- --------------------------------------------
Jean Deleage, President Alix Marduel, Managing Director
ALTA BIOPHARMA MANAGEMENT PARTNERS, LLC ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC
By: /s/ Alix Marduel By: /s/ Jean Deleage
----------------------------------------- --------------------------------------------
Alix Marduel, Member Jean Deleage, Member
THE MEDICINES COMPANYCHASE PARTNERS (ALTA BIO), LLC ALTA/CHASE BIOPHARMA MANAGEMENT, LLC
By: Alta/Chase BioPharma Management, LLC
By: /s/ Alix Marduel By: /s/ Alix Marduel
----------------------------------------- --------------------------------------------
Alix Marduel, Member Alix Marduel, Member
/s/ Jean Deleage /s/ Guy Nohra
-------------------------------------------- -----------------------------------------------
Jean Deleage Guy Nohra
/s/ Garrett Gruener /s/ Alix Marduel
-------------------------------------------- -----------------------------------------------
Garrett Gruener Alix Marduel
/s/ Daniel Janney
--------------------------------------------
Daniel Janney
EXHIBIT A
AGREEMENT OF JOINT FILING
We, the undersigned, hereby express our agreement that the attached
Schedule 13G is filed on behalf of us.
Date: April 4, 2002
ALTA PARTNERS ALTA BIOPHARMA PARTNERS, L.P.
By: Alta BioPharma Management Partners, LLC
By: /s/ Jean Deleage By: /s/ Alix Marduel
----------------------------------------- -----------------------------------------
Jean Deleage, President Alix Marduel, Managing Director
ALTA BIOPHARMA MANAGEMENT PARTNERS, LLC ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC
By: /s/ Alix Marduel By: /s/ Jean Deleage
----------------------------------------- -----------------------------------------
Alix Marduel, Member Jean Deleage, Member
THE MEDICINES COMPANYCHASE PARTNERS (ALTA BIO), LLC ALTA/CHASE BIOPHARMA MANAGEMENT, LLC
By: Alta/Chase BioPharma Management, LLC
By: /s/ Alix Marduel By: /s/ Alix Marduel
----------------------------------------- -----------------------------------------
Alix Marduel, Member Alix Marduel, Member
/s/ Jean Deleage /s/ Guy Nohra
-------------------------------------------- --------------------------------------------
Jean Deleage Guy Nohra
/s/ Garrett Gruener /s/ Alix Marduel
-------------------------------------------- --------------------------------------------
Garrett Gruener Alix Marduel
/s/ Daniel Janney
--------------------------------------------
Daniel Janney
Attachment A
EXIT FILING
Alta Partners provides investment advisory services to several venture capital
funds including Alta BioPharma Partners, L.P., The Medicines Company Chase
Partners (Alta Bio), LLC and Alta Embarcadero BioPharma Partners, LLC.
Stock Sale: On March 28, 2002, Alta BioPharma Partners, L.P. sold 41,958 shares
of Common Stock, The Medicines Company Chase Partners (Alta Bio), LLC sold
23,961 shares of Common Stock, and Alta Embarcadero BioPharma Partners, LLC sold
1,581 shares of Common Stock. These shares were sold on the public stock market.
Stock Distribution: On April 2, 2002, Alta BioPharma Partners, L.P. distributed
1,041,792 shares of Common Stock to its general and limited partners. The
Medicines Company Chase Partners (Alta Bio), LLC distributed 594,962 shares of
Common Stock to its members. Alta Embarcadero BioPharma Partners, LLC
distributed 39,265 shares of Common Stock to its members.
As a result of the Stock Sale and Stock Distribution Alta Partners is no longer
a 5% owner of the Company: Alta BioPharma Partners, L.P. beneficially owns
341,844 shares of Common Stock and Warrants for 178,987 shares of Common Stock.
The Medicines Company Chase Partners (Alta Bio), LLC beneficially owns 195,226
shares of Common Stock and Warrants for 102,218 shares of Common Stock. Alta
Embarcadero BioPharma Partners, LLC beneficially owns 12,885 shares of Common
Stock and Warrants for 6,746 shares of Common Stock. The respective general
partners and managing members of Alta BioPharma Partners, L.P., The Medicines
Company Chase Partners (Alta Bio), LLC and Alta Embarcadero BioPharma Partners,
LLC exercise sole voting and investment power with respect to the shares owned
by such funds.
Certain Principals of Alta Partners are managing directors of Alta BioPharma
Management, LLC (the general partner of Alta BioPharma Partners, L.P.), managing
members of Alta/Chase Management, LLC (the managing member of The Medicines
Company Chase Partners (Alta Bio), LLC), and members of Alta Embarcadero
BioPharma, LLC. As managing directors, managing members and members
(respectively), they may be deemed to share voting and investment powers over
the shares held by the funds. These principals disclaim beneficial ownership of
all such shares held by the aforementioned funds, except to the extent of their
proportionate pecuniary interests therein.
Mr. Jean Deleage is a managing director of Alta BioPharma Management, LLC (which
is the general partner of Alta BioPharma Partners, L.P.), a managing director of
Alta/Chase Management, LLC (which is the managing member of The Medicines
Company Chase Partners (Alta Bio), LLC) and a member of Alta Embarcadero
BioPharma Partners, LLC. Thus he shares voting and dispositive powers over the
341,844 shares of Common Stock and the Warrants for 178,987 shares of Common
Stock beneficially owed by Alta BioPharma Partners, L.P.; the 195,226 shares of
Common Stock and the Warrants for 102,218 shares of Common Stock beneficially
owned by The Medicines Company Chase Partners (Alta Bio), LLC; and the 12,885
shares of Common Stock and the Warrants for 6,746 shares of Common Stock
beneficially owned by Alta Embarcadero BioPharma Partners, LLC. Mr. Deleage
disclaims beneficial ownership of the shares held by the aforementioned funds
except to the extent of his proportionate pecuniary interests therein. On April
2, 2002, Mr. Deleage received 10,172 shares of Common Stock, which was his
proportionate pecuniary interest in the stock distributions for Alta Embarcadero
BioPharma Partners, LLC, Alta BioPharma Management, LLC and Alta/Chase BioPharma
Management, LLC. See next page for disclosure of share ownership.
Page 1 of 3 of Attachment A
Page 2 of 3 of Attachment A
As of April 2, 2002 --- Common Stock Ownership: Shares Owned by / Affiliated
with Jean Deleage
Beneficial Owner (issued in the name of) # of Shares Date Acquired
Jean Deleage 10,172 April 2, 2002
Deleage Children's Trust FBO Andre Deleage (1) 2,711 April 2, 2002
Deleage Children's Trust FBO Emmanuel Deleage (1) 2,711 April 2, 2002
Deleage Children's Trust FBO Phillippe Deleage (1) 2,711 April 2, 2002
Deleage Children's Trust FBO Michel Deleage (1) 2,710 April 2, 2002
(1) Of which Mr. Deleage, a principal of Alta Partners (a venture capital firm)
is neither a trustee nor claims any beneficial ownership.
Mr. Garrett Gruener is a managing director of Alta BioPharma Management, LLC
(which is the general partner of Alta BioPharma Partners, L.P.), a managing
director of Alta/Chase Management, LLC (which is the managing member of The
Medicines Company Chase Partners (Alta Bio), LLC) and a member of Alta
Embarcadero BioPharma Partners, LLC. Thus he shares voting and dispositive
powers over the 341,844 shares of Common Stock and the Warrants for 178,987
shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P.; the
195,226 shares of Common Stock and the Warrants for 102,218 shares of Common
Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio),
LLC; and the 12,885 shares of Common Stock and the Warrants for 6,746 shares of
Common Stock beneficially owned by Alta Embarcadero BioPharma Partners, LLC. Mr.
Gruener disclaims beneficial ownership of the shares held by the aforementioned
funds except to the extent of his proportionate pecuniary interests therein. On
April 2, 2002, Mr. Gruener received 13,742 shares of Common Stock, which was his
proportionate pecuniary interest in the stock distributions for Alta Embarcadero
BioPharma Partners, LLC, Alta BioPharma Management, LLC and Alta/Chase BioPharma
Management, LLC.
Mr. Daniel Janney is a managing director of Alta BioPharma Management, LLC
(which is the general partner of Alta BioPharma Partners, L.P.), and a managing
director of Alta/Chase Management, LLC (which is the managing member of The
Medicines Company Chase Partners (Alta Bio), LLC). Thus he shares voting and
dispositive powers over the 341,844 shares of Common Stock and the Warrants for
178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners,
L.P., and the 195,226 shares of Common Stock and the Warrants for 102,218 shares
of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta
Bio), LLC. Mr. Janney disclaims beneficial ownership of the shares held by the
aforementioned funds except to the extent of his proportionate pecuniary
interests therein. On April 2, 2002, Mr. Janney received 18,070 shares of Common
Stock, which was his proportionate pecuniary interest in the stock distributions
for Alta BioPharma Management, LLC and Alta/Chase BioPharma Management, LLC.
Dr. Alix Marduel is a managing director of Alta BioPharma Management, LLC (which
is the general partner of Alta BioPharma Partners, L.P.), and a managing
director of Alta/Chase Management, LLC (which is the managing member of The
Medicines Company Chase Partners (Alta Bio), LLC). Thus she shares voting and
dispositive powers over the 341,844 shares of Common Stock and the Warrants for
178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners,
L.P., and the 195,226 shares of Common Stock and the Warrants for 102,218 shares
of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta
Bio), LLC. Dr. Marduel disclaims beneficial ownership of the shares held by the
aforementioned funds except to the extent of her proportionate pecuniary
interests
Page 3 of 3 of Attachment A
therein. On April 2, 2002, Dr. Marduel received 18,070 shares of Common Stock,
which was her proportionate pecuniary interest in the stock distributions for
Alta BioPharma Management, LLC and Alta/Chase BioPharma Management, LLC.
Mr. Guy Nohra is a managing director of Alta BioPharma Management, LLC (which is
the general partner of Alta BioPharma Partners, L.P.), and a managing director
of Alta/Chase Management, LLC (which is the managing member of The Medicines
Company Chase Partners (Alta Bio), LLC). Thus he shares voting and dispositive
powers over the 341,844 shares of Common Stock and the Warrants for 178,987
shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P., and
the 195,226 shares of Common Stock and the Warrants for 102,218 shares of Common
Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio),
LLC. Mr. Nohra disclaims beneficial ownership of the shares held by the
aforementioned funds except to the extent of his proportionate pecuniary
interests therein. On April 2, 2002, Mr. Nohra received 13,251 shares of Common
Stock, which was his proportionate pecuniary interest in the stock distributions
for Alta BioPharma Management, LLC and Alta/Chase BioPharma Management, LLC.
Alta Partners is a venture capital firm with an office in San Francisco. Alta
Partners is California Corporation. Alta BioPharma Partners, L.P. is a Delaware
Limited Partnership, The Medicines Company Chase Partners (Alta Bio), LLC is a
Delaware Limited Liability Company, and Alta Embarcadero BioPharma Partners, LLC
is a California Limited Liability Company.