SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)


             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)

                                (Amendment No. 2)


                               DOR BioPharma, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                         Common Stock, par value $0.001
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    258094101
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 2005
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


     Check the  appropriate  box to  designate  the rule  pursuant to which this
Schedule is filed:

          [_]  Rule 13d-1(b)

          [x]  Rule 13d-1(c)

          [_]  Rule 13d-1(d)

CUSIP No.   258094101
            ---------------------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Silverback Asset Management, LLC

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                 (a)  [_]
                                                                 (b)  [_]
3.   SEC USE ONLY


4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

     0

6.   SHARED VOTING POWER

     3,837,700*

7.   SOLE DISPOSITIVE POWER

     0

8.   SHARED DISPOSITIVE POWER

     3,837,700*

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     3,837,700*

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                                                          [_]
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     7.6%

12.  TYPE OF REPORTING PERSON

     CO

* Silverback Asset Management, LLC ("SAM") serves as investment manager to
Silverback Master, Ltd. ("Silverback Master") and certain other private
investment vehicles. In its capacity as investment manager of such private
investment vehicles, including Silverback Master, SAM may be deemed to be the
beneficial owner of securities held by each such private investment vehicle. SAM
disclaims beneficial ownership of the securities reported in this Schedule 13G
except to the extent of its pecuniary interest therein, and the filing of this
Schedule 13G shall not be construed as an admission that SAM is, for the
purposes of Section 13(d) or 13(g) of the Act, the beneficial owner of any
securities reported in this Schedule 13G except to the extent of its pecuniary
interest therein.

CUSIP No.   258094101
            ---------------------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Silverback Master, Ltd.

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                 (a)  [_]
                                                                 (b)  [_]
3.   SEC USE ONLY


4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Cayman Islands

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

     0

6.   SHARED VOTING POWER

     3,108,000

7.   SOLE DISPOSITIVE POWER

     0

8.   SHARED DISPOSITIVE POWER

     3,108,000

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     3,108,000

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                                                          [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     6.1%

12.  TYPE OF REPORTING PERSON

     CO

CUSIP No.   258094101
            ---------------------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Elliot Bossen

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                 (a)  [_]
                                                                 (b)  [_]
3.   SEC USE ONLY


4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     United States of America

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

     0

6.   SHARED VOTING POWER

     3,837,700**

7.   SOLE DISPOSITIVE POWER

     0

8.   SHARED DISPOSITIVE POWER

     3,837,700**

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     3,837,700**

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                                                          [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     7.6%

12.  TYPE OF REPORTING PERSON

     IN

** Elliot Bossen is the sole Managing Member of SAM and is primarily responsible
for the investment decisions of SAM. Elliot Bossen disclaims beneficial
ownership of the securities reported in this Schedule 13G except to the extent
of his pecuniary interest therein, and the filing of this Schedule 13G shall not
be construed as an admission that he is, for the purposes of Section 13(d) or
13(g) of the Act, the beneficial owner of any securities reported in this
Schedule 13G except to the extent of his pecuniary interest therein.

CUSIP No.   258094101
            ---------------------

Item 1(a).  Name of Issuer:

            DOR BioPharma, Inc.
            ____________________________________________________________________

Item 1(b).  Address of Issuer's Principal Executive Offices:

            1691 Michigan Ave., Suite 435
            Miami, FL  33139
            ____________________________________________________________________

Item 2(a).  Name of Person Filing:

            Silverback Asset Management, LLC
            Silverback Master, Ltd.
            Elliot Bossen
            ____________________________________________________________________

Item 2(b).  Address of Principal Business Office, or if None, Residence:

            Silverback Asset Management, LLC
            1414 Raleigh Road
            Suite 250
            Chapel Hill, NC  27517

            Silverback Master, Ltd.
            c/o International Fund Services (Ireland) Limited
            Bishop's Square, Third Floor
            Redmond's Hill
            Dublin 2, Ireland

            Elliot Bossen
            c/o Silverback Asset Management, LLC
            1414 Raleigh Road
            Suite 250
            Chapel Hill, NC  27517
            ____________________________________________________________________

Item 2(c).  Citizenship:

            Silverback Asset Management, LLC - Delaware
            Silverback Master, Ltd. - Cayman Islands
            Elliot Bossen - United States of America
            ____________________________________________________________________

Item 2(d).  Title of Class of Securities:

            Common Stock, par value $0.001
            ____________________________________________________________________

Item 2(e).  CUSIP Number:

            258094101
            ____________________________________________________________________

Item 3.     If This Statement  is Filed  Pursuant to  Rule 13d-1(b), or 13d-2(b)
            or (c), Check Whether the Person Filing is a:

     (a)  [_]  Broker or dealer registered under Section 15 of the Exchange Act.

     (b)  [_]  Bank as defined in Section 3(a)(6) of the Exchange Act.

     (c)  [_]  Insurance  company as defined in Section 3(a)(19) of the Exchange
               Act.

     (d)  [_]  Investment  company  registered under Section 8 of the Investment
               Company Act.

     (e)  [_]  An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

     (f)  [_]  An employee  benefit plan or endowment  fund in  accordance  with
               Rule 13d-1(b)(1)(ii)(F);

     (g)  [_]  A parent  holding  company or control  person in accordance  with
               Rule 13d-1(b)(1)(ii)(G);

     (h)  [_]  A savings  association  as defined in Section 3(b) of the Federal
               Deposit Insurance Act;

     (i)  [_]  A  church  plan  that  is  excluded  from  the  definition  of an
               investment  company  under  Section  3(c)(14)  of the  Investment
               Company Act;

     (j)  [_]  Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

Item 4.  Ownership.

     (a)  Amount beneficially owned:

          Silverback Asset Management, LLC - 3,837,700**
          Silverback Master, Ltd. - 3,108,000**
          Elliot Bossen - 3,837,700**
          ______________________________________________________________________

     (b)  Percent of class:

          Silverback Asset Management, LLC - 7.6%
          Silverback Master, Ltd. - 6.1%
          Elliot Bossen - 7.6%
          ______________________________________________________________________

     (c)  Number of shares as to which such person has:

Silverback Asset Management, LLC
--------------------------------

          (i)   Sole power to vote or to direct the vote                    0
                                                           ___________________,

          (ii)  Shared power to vote or to direct the vote          3,837,700
                                                           ___________________,

          (iii) Sole power to dispose or to direct the                      0
                disposition of                             ___________________,

          (iv)  Shared power to dispose or to direct the            3,837,700
                disposition of                             ____________________

Silverback Master, Ltd.
-----------------------

          (i)   Sole power to vote or to direct the vote                    0
                                                           ___________________,

          (ii)  Shared power to vote or to direct the vote          3,108,000
                                                           ___________________,

          (iii) Sole power to dispose or to direct the                      0
                disposition of                             ___________________,

          (iv)  Shared power to dispose or to direct the            3,108,000
                disposition of                             ___________________.

Elliot Bossen
-------------

          (i)   Sole power to vote or to direct the vote                    0
                                                           ___________________,

          (ii)  Shared power to vote or to direct the vote          3,837,700
                                                           ___________________,

          (iii) Sole power to dispose or to direct the                      0
                disposition of                             ___________________,

          (iv)  Shared power to dispose or to direct the            3,837,700
                disposition of                             ___________________.

Item 5.  Ownership of Five Percent or Less of a Class.

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities check the following [ ].

         N/A
         _______________________________________________________________________

Item 6.  Ownership of More Than Five Percent on Behalf of Another Person.

         N/A
         _______________________________________________________________________

Item 7.  Identification and  Classification of the Subsidiary Which Acquired the
         Security  Being  Reported on by the Parent  Holding  Company or Control
         Person.

         N/A
         _______________________________________________________________________

Item 8.  Identification  and  Classification  of Members of the Group.

         N/A
         _______________________________________________________________________

Item 9.  Notice of Dissolution of Group.

         N/A
         _______________________________________________________________________

Item 10.  Certifications.

          By signing  below I certify  that,  to the best of my  knowledge  and
          belief, the securities referred to above were not acquired and are not
          held for the purpose of or with the effect of changing or  influencing
          the control of the issuer of the  securities and were not acquired and
          are not held in connection with or as a participant in any transaction
          having such purpose or effect.




                                    SIGNATURE

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


                                                   February 14, 2006
                                        ----------------------------------------
                                                        (Date)

                                        Silverback Asset Management, LLC

                                        By: /s/ Elliot Bossen
                                        --------------------------------
                                            Name: Elliot Bossen
                                            Title: Managing Member


                                        Silverback Master, Ltd.

                                        By: /s/ Elliot Bossen
                                        --------------------------------
                                            Name: Elliot Bossen
                                            Title: Director



                                         /s/ Elliot Bossen
                                         -------------------------------
                                             Elliot Bossen






Exhibit A
---------



     The undersigned agree that this Amendment No. 2 Schedule 13G dated February
13, 2006 relating to the Common Stock, par value $0.001, of DOR BioPharma, Inc.
is being filed on behalf of each of Silverback Asset Management, LLC, Silverback
Master, Ltd. and Elliot Bossen.

                                                   February 14, 2006
                                        ----------------------------------------
                                                        (Date)



                                        Silverback Asset Management, LLC

                                        By: /s/ Elliot Bossen
                                        --------------------------------
                                            Name: Elliot Bossen
                                            Title: Managing Member


                                        Silverback Master, Ltd.

                                        By: /s/ Elliot Bossen
                                        --------------------------------
                                            Name: Elliot Bossen
                                            Title: Director



                                         /s/ Elliot Bossen
                                         -------------------------------
                                             Elliot Bossen




SK 04098 0001 643440