Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Furse Brent
 2. Date of Event Requiring Statement (Month/Day/Year)
03/03/2014		 3. Issuer Name and Ticker or Trading Symbol
MEDICINES CO /DE [MDCO]
(Last)
(First)
(Middle)
8 SYLVAN WAY		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
EVP, Chief Customer Officer
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

PARSIPPANY, NJ 07054		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 40,629 (1) (2)
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right-to-buy)   (3) 02/16/2017 Common Stock 13,000 $ 28.6 D  
Stock Option (right-to-buy)   (4) 02/19/2020 Common Stock 1,458 $ 7.31 D  
Stock Option (right-to-buy)   (5) 02/18/2021 Common Stock 11,111 $ 17.45 D  
Stock Option (right-to-buy)   (6) 02/24/2022 Common Stock 17,500 $ 22.04 D  
Stock Option (right-to-buy)   (7) 03/01/2023 Common Stock 15,373 $ 31.49 D  
Stock Option (right-to-buy)   (8) 03/01/2024 Common Stock 25,072 $ 30.55 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Furse Brent
8 SYLVAN WAY
PARSIPPANY, NJ 07054		       EVP, Chief Customer Officer  

Signatures

/s/ Stephen M. Rodin, Attorney-in-Fact for Brent Furse 03/04/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Includes 32,501 shares of restricted stock that vest in 25% increments on each anniversary of the date of grant, until fully vested.
(2) The reporting person was appointed Executive Vice President, Chief Customer Officer and Regional Engagement Leader - Americas of the Issuer effective March 3, 2014.
(3) Represents a grant made to the reporting person on February 16, 2007. The option vested in forty-eight equal installments beginning March 16, 2007.
(4) Represents the remainder of a grant of 17,500 stock options made to the reporting person on February 19, 2010. The remaining option vests in equal monthly installments ending on March 19, 2014.
(5) Represents the remainder of a grant of 33,333 stock options made to the reporting person on February 18, 2011. The remaining option vests in equal monthly installments ending on March 18, 2015.
(6) Represents the remainder of a grant of 30,000 stock options made to the reporting person on February 24, 2012. The remaining option vests in equal monthly installments ending on March 24, 2016.
(7) Represents a grant made to the reporting person on March 1, 2013. The option vests in forty-eight equal installments ending April 1, 2017.
(8) presents a grant made to the reporting person on March 1, 2013. The option vests in forty-eight equal installments ending April 1, 2018.

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