Concerns about potential new trading regulations in China sent the markets tumbling to a sharply lower open with Dow plummeting 258 points to 17,847. Nasdaq plunged 71 points to 4,935.

On the upside

Celanese (NYSE: CE) reported higher first quarter earnings that beat analyst expectations.

Novogen (Nasdaq: NVGN) will collaborate with the Feinstein Institute for Medical Research to develop brain cancer treatments.

Shares of Rosetta Genomics (Nasdaq: ROSG) continued rising.

On the downside

Athersys (Nasdaq: ATHX) reported disappointing results from a Phase 2 study of its MultiStem cell therapy to treat ischemic stroke patients.

Advanced Micro Devices (Nasdaq: AMD) widened first quarter losses more than expected as revenue dropped.

ServiceNow (NYSE: NOW) widened losses for the first quarter and forecast current quarter revenue below analyst estimates.
 
In the broad market, declining issues outpaced advancers by a margin of more than 4 to 1 on both the NYSE and on Nasdaq. The broader S&P 500 plunged 22 points to 2082. Bitcoin lost $5 to $222.