Jobless claims unexpectedly rose last week to weigh the markets down to a lower close with the Dow falling 36 points to 18,126. Nasdaq slipped 8 points to 5,097.

On the upside

Shares of Signal Genetics (Nasdaq: SGNL) continued climbing.

A federal judge granted Amarin’s (Nasdaq: AMRN) request for a summary judgment in the biopharmaceutical’s suit seeking Food and Drug Administration recognition of a five-year marketing exclusivity for Vascepa.

GoPro (Nasdaq: GPRO) chief executive Nick Woodman announced plans to develop a quadcopter and a Six-Camera Spherical Array.
 
On the downside

Investors locked in profits on Ceres (Nasdaq: CERE).

United Rentals (NYSE: URI) chief executive Michael Kneeland indicated that May revenue would fall short of expectations.

Profit taking weighed down shares of Delcath Systems (Nasdaq: DCTH).
 
In the broad market, declining issues outpaced advancers by a margin of nearly 7 to 5 on the NYSE and by more than 10 to 9 on Nasdaq. The broader S&P 500 slipped 2 points to 2120. Bitcoin added $1 to $237.