Cognigenics, a pioneering company in RNA-based therapeutics for neuropsychiatric conditions and neurocognitive disorders, announced the publication of its latest research, Treatment with shRNA to Knockdown the 5-HT2A Receptor Improves Memory In Vivo and Decreases Excitability in Primary Cortical Neurons.

This groundbreaking work illustrates the possibility of applying short hairpin RNA (shRNA) technology in an RNA interference application to improve memory and significantly lower neural excitability. This approach could represent a significant development in treating neurocognitive and neuropsychiatric diseases.

The research conducted by a group of highly regarded neuroscientists at Cognigenics sheds light on the possibility of using short hairpin RNA (shRNA) to target and down-regulate the 5-HT2A receptor. This results in neuronal stability (returning the neurons to their healthy natural state) and considerable cognitive improvements in preclinical trials. This revolutionary technique has demonstrated encouraging outcomes in both in vivo and in vitro models, paving the path for developing novel treatment approaches for a wide range of neurocognitive difficulties.

Dr. Troy Rohn, Director of Preclinical Studies at Cognigenics, expressed his excitement:

"Our research underscores the transformative potential of shRNA technology in treating neurocognitive disorders. By precisely targeting the 5-HT2A receptor, our study demonstrates improved memory function and reduced neuronal hyperactivity, offering a potential new therapeutic approach for patients suffering from cognitive impairments and anxiety-related disorders."

David Pyrce, Chief Executive Officer, also commented on the publication:

"This study is a testament to Cognigenics' commitment to advancing neurocognitive therapies of the next generation through cutting-edge research in genetic medicine," said David Pyrce, CEO. "Specifically, it illustrates the strong possibility of using therapeutics based on shRNA to address substantial medical needs that are now unmet. Receiving this information strengthens our ambition of developing novel, noninvasive treatments and delivering such therapies to patients as rapidly as feasible."

Continuous improvements in developing and improving genetic treatments are evidence of Cognigenics' commitment to offering high-impact, ground-breaking medicines that target neurocognitive diseases. These therapies are intended to treat neurocognitive disorders. The firm's unique platform is designed to use shRNA and other RNA-based technologies to provide long-term solutions with undetected off-target effects. This platform has the potential to establish a new standard within the industry.

"This publication is more than just a scientific achievement; it represents a significant step forward in our mission to transform mental health treatment," said Dr. Rohn in conclusion. "The field of cognigenics is at the forefront of developing truly innovative therapeutic approaches beyond managing symptoms. Instead, it concentrates on applying precision medicine tools to provide patients in need with comprehensive and long-term solutions."

The Cognigenics Approach

Cognigenics is at the forefront of the development of RNA-based treatments for mental health to treat neuropsychiatric and neurocognitive disorders. By applying cutting-edge genetic neuroengineering techniques, Cognigenics develops novel therapies for illnesses such as memory loss, anxiety, and cognitive impairments. Cognigenics is committed to developing medicines that provide long-term benefits with minimal side effects, transforming mental health care delivery.

For more information about Cognigenics and the Team’s Research

www.cognigenics.io.

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