SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE TO/A
                                (AMENDMENT NO. 1)

        TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR SECTION 13(E)(1)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                                (Name of Issuer)

               INTEGRA LIFESCIENCES HOLDINGS CORPORATION (ISSUER)
 (Name of Filing Person (Identifying Status as Offeror, Issuer or Other Person))

            2 1/2% CONTINGENT CONVERTIBLE SUBORDINATED NOTES DUE 2008
                         (Title of Class of Securities)

                      (CUSIP NOS. 457985AA7 AND 457985AB5)
                      (CUSIP Number of Class of Securities)

                              MAUREEN B. BELLANTONI
              EXECUTIVE VICE PRESIDENT AND CHIEF FINANCIAL OFFICER
                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                              311 ENTERPRISE DRIVE
                          PLAINSBORO, NEW JERSEY 08536
                                 (609) 275-0500

           (Name, Address and Telephone Number of Person Authorized to
      Receive Notices and Communications on Behalf of the Filing Person(s))

                                    COPY TO:
                              PETER LABONSKI, ESQ.
                              LATHAM & WATKINS LLP
                                885 THIRD AVENUE
                               NEW YORK, NY 10022
                                 (212) 906-1200


                            CALCULATION OF FILING FEE

TRANSACTION VALUATION*                               AMOUNT OF FILING FEE**
----------------------                              ------------------------
    $120,000,000                                            $12,840

*        Calculated  solely  for the  purpose of  determining  the amount of the
         filing fee, based upon the exchange of $120,000,000 aggregate principal
         amount of the Issuer's 2 1/2% Contingent Convertible Subordinated Notes
         due 2008 in exchange for Integra LifeSciences Holdings  Corporation's 2
         1/2% Contingent Convertible Subordinated Notes due 2008.

**       Previously paid.

[ ]      Check  box if any  part  of the fee is  offset  as  provided  by Rule
         0-11(a)(2)  and identify the filing with which the  offsetting  fee was
         previously paid. Identify the previous filing by registration statement
         number, or the form or schedule and the date of its filing.

  Amount Previously Paid:   Not applicable.      Filing party:   Not applicable.
  Form or Registration No.:   Not applicable.     Date Filed:   Not applicable.

[ ] Check the box if the filing  relates  solely to  preliminary  communications
made before the commencement of a tender offer.



Check the  appropriate  boxes below to designate any  transactions  to which the
statement relates:

         [ ]third-party tender offer subject to Rule 14d-1

         [X]issuer tender offer subject to Rule 13e-4

         [ ]going private transaction subject to Rule 13e-3

         [ ]amendment to Schedule 13D under Rule 13d-2

Check the following box if the filing is a final amendment reporting the results
of the tender offer [ ]

                                       2



                  This Amendment No. 1 to Schedule TO (this "Amendment")  amends
and  supplements the Tender Offer Statement on Schedule TO ("Schedule TO") filed
by Integra  LifeSciences  Holdings  Corporation,  a Delaware  corporation,  (the
"Issuer") on July 17, 2006.  This  Amendment  relates to the offer by the Issuer
(i) to exchange  $1,000 in  principal  amount of 2 1/2%  Contingent  Convertible
Subordinated  Notes due 2008 (the "New  Notes") and (ii) a one time cash payment
(an  "Exchange  Fee") equal to $2.50 for each $1,000 in principal  amount of the
Issuer's outstanding 2 1/2% Contingent  Convertible  Subordinated Notes due 2008
(the "Old Notes" and together with the New Notes,  the "Notes") that is properly
tendered and accepted for exchange upon the terms and subject to the  conditions
set forth in the Offer to Exchange (this "Offer to Exchange") and in the related
Letter of Transmittal (the "Letter of Transmittal"), as each may be amended from
time to time.  The offer to  exchange  the Notes  (including  the  payment of an
Exchange  Fee)  pursuant  to the Offer to  Exchange  is referred to herein as an
"Offer." This Amendment  amends and supplements  Schedule TO as set forth below.
This  Amendment  is filed to satisfy the  reporting  requirements  of Rule 13e-4
under the Securities Exchange Act of 1934, as amended.

                  The  information  in the  Offer to  Exchange  and the  related
Letter of Transmittal,  copies of which were previously  filed on Schedule TO as
exhibits (a)(1)(i) and (a)(1)(ii)  thereto, is incorporated in this Amendment by
reference,  except that such  information is hereby amended and  supplemented to
the extent specifically provided herein.

INTRODUCTION

          (1) The final two sentences of the first  paragraph of the Schedule TO
     are  hereby  deleted  and  replaced  with  the  following:  "The  Offer  is
     contingent  upon the tender or  exchange  of at least 50% of the  principal
     amount of Old Notes  outstanding  and the  satisfaction  of  certain  other
     conditions."

ITEMS 1, 4, 6, 7 AND 11

         Items  1, 4,  6, 7 and 11 of the  Schedule  TO,  which  incorporate  by
reference the information contained in the Offer to Exchange, are hereby amended
and supplemented as follows:

          (2) The last  sentence of the second  paragraph on page 1 of the Offer
     to Exchange under the heading "Summary" is hereby deleted.

          (3) The first  paragraph on page 5 of the Offer to Exchange  under the
     heading  "New  Notes" is hereby  amended and  restated  in its  entirety as
     follows:

          The following  summary contains basic information about the New Notes.
          For a  complete  understanding  of the New Notes and before you decide
          whether  to tender  your Old Notes in the Offer,  please  refer to the
          section of this  document  entitled  "Description  of New  Notes." For
          purposes of the description of the New Notes included in this Offer to
          Exchange,  references  to "the  Company,"  "Integra,"  "us," "we," and
          "our" refer only to Integra  LifeSciences  Holdings Corporation and do
          not include our subsidiaries.

          (4) The first sentence of the last paragraph on page 6 of the Offer to
     Exchange under the heading "New Notes--Conversion Rights" is hereby amended
     and replaced in its entirety with the following:

          Upon conversion of each $1,000 principal amount of New Notes, you will
          receive:  (a) cash and (b) common stock,  determined in the manner set
          forth herein.

                                       3





          (5) On page 10 of the Offer to Exchange, the section entitled "Summary
     Comparison of the Old Notes and the New Notes" is hereby amended to add the
     following subsection under "--Maturity":




                                                                                      
     Subordination........................ The Old Notes are unsecured, subordinated        Same as the Old Notes.
                                           obligations of the Company.  They rank junior
                                           in right of payment to all of the Company's
                                           existing and future senior indebtedness (as
                                           defined), and rank equally with all of our
                                           future subordinated indebtedness.  The notes
                                           are also effectively subordinated to all
                                           existing and future indebtedness and other
                                           liabilities of our subsidiaries.  Neither we
                                           nor our subsidiaries are restricted under the
                                           indenture from incurring senior debt or other
                                           additional indebtedness.




          (6) The disclosure in the New Notes column "Summary  Comparison of the
     Old Notes and the New  Notes--Conversion  Price" on page 11 of the Offer to
     Exchange is hereby amended and replaced in its entirety with the following:

          Same as the Old Notes,  except  that,  subject  to certain  exceptions
          described  in  "Description  of New Notes,"  upon  conversion  of each
          $1,000 principal  amount of New Notes,  holders will receive cash and,
          if applicable,  shares of our common stock in an amount  determined in
          the manner set forth under  "Description  of New  Notes--Payment  Upon
          Conversion."  The amount of cash and common stock  payable will depend
          upon the value of our common  stock over a 15 day  observation  period
          beginning on the third trading day after a holder delivers a notice of
          conversion.

          (7) The last  sentence  of the  paragraph  on page 31 of the  Offer to
     Exchange  under the  heading  "Selected  Financial  Information"  is hereby
     deleted.

          (8) The first  bullet  under the  heading  "Important  Reservation  of
     Rights  Regarding  the Offer" on page 34 of the Offer to Exchange is hereby
     amended and restated in its entirety as follows:

          All questions as to the validity,  form, eligibility,  time of receipt
          and  acceptance  of Old Notes  tendered for  exchange,  including  the
          Letter  of  Transmittal  and  the   instructions  to  such  Letter  of
          Transmittal,  will be determined by us in our sole  discretion and our
          determination shall be final and binding on all persons  participating
          in the  Offer,  subject  to such Offer  participant's  disputing  such
          determination in a court of competent jurisdiction.

          (9) The  penultimate  bullet on page 35 of the Offer to Exchange under
     the heading "Important Reservation of Rights Regarding the Offer" is hereby
     amended and restated in its entirety as follows:

          We  also  reserve  the   absolute   right  to  waive  any  defects  or
          irregularities  or  conditions of the Offer as to any  particular  Old
          Notes, other than those conditions that are dependent upon the receipt
          of government  approvals,  before the Expiration  Date. In the case of
          those  conditions of the Offer that are dependent  upon the receipt of
          government  approvals,  we reserve  the  absolute  right to waive such
          conditions before or after the Expiration Date.


                                       4



          (10) The last sentence in the first paragraph under the heading "Legal
     Limitation"  on page 36 of the  Offer to  Exchange  is hereby  deleted  and
     replaced in its entirety with the following:

          Any determination by us concerning the conditions described above will
          be final  and  binding  on all  parties  participating  in the  Offer,
          subject to such Offer participant's  disputing such determination in a
          court of competent jurisdiction.

          (11) The  penultimate  paragraph  on page 40 of the Offer to  Exchange
     under the heading "Withdrawal of Tenders" is hereby amended and restated in
     its entirety as follows:

          All questions as to form and validity  (including  time of receipt) of
          any delivery or  revocation  of a tender will be  determined by us, in
          our sole discretion,  which determination will be final and binding on
          all  persons  participating  in  the  Offer,  subject  to  such  Offer
          participant's  disputing  such  determination  in a court of competent
          jurisdiction.

          (12) The first full  paragraph  on page 48 of the Offer to Exchange is
     hereby amended to add the following sentence prior to the final sentence of
     the paragraph:

          At our option,  we may issue one share of our common stock  instead of
          paying cash in lieu of fractional shares.

          (13)  The   disclosure   under  the   heading   "Description   of  New
     Notes--Payment  Upon  Conversion"  on page 48 of the Offer to  Exchange  is
     hereby amended and replaced in its entirety with the following:

          Upon conversion of a holder's New Note, we shall deliver,  through the
          conversion  agent,  the  following  to such  holder  for  each  $1,000
          principal amount of New Notes being converted, subject to our right to
          elect to pay the net share  amount in cash:  (1) cash equal to the sum
          of the daily cash  amounts (as defined  below),  and (2) shares  ("net
          shares") of common stock, if any, with a value equal to the sum of the
          daily share amounts (as defined  below) (the "net share  amount"),  in
          each  case  for  each  of the  15  trading  days  during  the  related
          observation  period.  We shall  deliver  the  foregoing  on the  third
          trading  day  immediately  following  the  last  day  of  the  related
          observation period.

          The "observation  period" with respect to any New Note converted means
          the 15 consecutive  trading-day  period beginning on and including the
          third trading day after a holder  delivers a conversion  notice to the
          conversion  agent  or,  if the we have  elected  to pay the net  share
          amount in cash,  the trading day after the last day of the  conversion
          retraction  period.

          The "daily settlement  amount," for each of the 15 trading days during
          the observation period, shall consist of:

     o    cash (the "daily cash  amount")  equal to the lesser of $66.67 and the
          daily conversion value relating to such day; and

     o    if such daily  conversion  value exceeds $66.67, a number of shares of
          common stock with a value (the "daily share  amount") equal to (A) the
          difference between such daily conversion value and $66.67,  divided by
          (B) the daily VWAP for such day.

          Instead of delivering  shares of common stock in  satisfaction  of our
          obligation  to deliver the net share amount upon  conversion of Notes,
          we may elect to deliver an additional amount of cash. The amount shall
          be equal to the net share amount.


                                       5



          We will inform the holders through the trustee if we choose to satisfy
          our  obligation to deliver the net share amount upon  conversion  with
          additional   cash  no  later  than  two  trading  days  following  the
          conversion date.

          If we do not give any notice  within the time periods  described as to
          how we intend to settle, we will satisfy our obligation to deliver the
          net share  amount only in shares of common  stock (and cash in lieu of
          fractional  shares).  We will  treat in the same  manner  all  holders
          converting on the same trading day. Subject to the foregoing,  we will
          not, however, have any obligation to settle our conversion obligations
          arising on  different  trading  days in the same  manner.  For holders
          converting  on any trading  day, we may choose to settle the net share
          amount  in cash and  shares  of  common  stock  only  and for  holders
          converting on another  trading day,  choose to settle  exclusively  in
          cash.

          If we elect to satisfy  any portion of our  obligation  to deliver the
          net  share  amount  in cash  (other  than  cash in lieu of  fractional
          shares),  holders  may  retract  their  conversion  notice at any time
          during the three trading day period beginning on the trading day after
          we have notified the trustee of our method of settlement.

          The "daily  conversion  value" means,  for each of the 15  consecutive
          trading days during the observation  period,  one-fifteenth  (1/15) of
          the product of (1) conversion  rate on such day and (2) the daily VWAP
          of common  stock (or the value of the  securities  into  which  common
          stock has been converted) for such day.

          The  "daily  VWAP"  for the  common  stock  means,  for each of the 15
          consecutive  trading days during the observation period, the per share
          volume-weighted   average   price  as  displayed   under  the  heading
          "Bloomberg VWAP" on Bloomberg page IART [EQUITY] AQR in respect of the
          period  from 9:30  a.m.  to 4:00  p.m.  (New  York City  time) on such
          trading day (or if such volume-weighted  average price is unavailable,
          the market  value of one share of common  stock on such trading day as
          the   board  of   directors   determines   in  good   faith   using  a
          volume-weighted method, which determination shall be conclusive).

          (14)  The  last   sentence   in  the   paragraph   under  the  heading
     "Calculations  in Respect of New Notes" on page 56 of the Offer to Exchange
     is hereby amended and restated in its entirety as follows:

          We will make all these calculations in good faith and, absent manifest
          error,  our  calculations  will be final and binding on holders of New
          Notes,  subject to such holder's disputing such calculation in a court
          of competent jurisdiction.

          (15) The penultimate and last sentences of the first paragraph on page
     58 of the Offer to  Exchange  under the  heading  "Description  of  Capital
     Stock" are hereby deleted.

          (16) The third sentence of the third paragraph on page 71 of the Offer
     to Exchange  under the  heading  "Where You Can Find More  Information"  is
     hereby deleted.

          (17) The second  bullet on page 71 of the Offer to Exchange  under the
     heading  "Where  You Can Find  More  Information"  is  hereby  amended  and
     restated in its entirety as follows:

          Current  Reports on Form 8-K filed on January  9,  2006,  January  17,
          2006,  March 8, 2006 (as  amended on May 12,  2006),  March 10,  2006,
          April 13, 2006,  April 25, 2006,  May 17, 2006 (as amended on July 28,
          2006), July 7, 2006, July 14, 2006 and July 17, 2006; and

ITEM 12.  EXHIBITS.

         Item 12 of the Schedule TO is hereby amended and supplemented by adding
the following exhibits:


                                       6



(a)(i)(vi) Supplement to Offer to Exchange, dated July 31, 2006.

(a)(5)(ii) Press Release, dated July 31, 2006.

Letter of Transmittal

          (1) The first  sentence  of the  second  paragraph  under  "Item 8. No
     Conditional  Tenders"  on page 14 of the  Letter of  Transmittal  is hereby
     amended and restated in its entirety as follows:

          The Company will determine,  in its sole discretion,  all questions as
          to the form,  validity,  eligibility  (including  time of receipt) and
          acceptance   for   exchange   of  any  tender  of  Old  Notes,   which
          determination  will be final and binding on all persons  participating
          in the  Offer,  subject  to such Offer  participant's  disputing  such
          determination in a court of competent jurisdiction.

          (2) The third  sentence  of the  second  paragraph  under  "Item 8. No
     Conditional  Tenders"  on page 14 of the  Letter of  Transmittal  is hereby
     amended and restated in its entirety as follows:

          The Company also reserves the absolute right, in its sole  discretion,
          to waive any defects or  irregularities  or conditions of the Offer as
          to any  particular  Old Notes,  other than  those  dependent  upon the
          receipt of government approvals, before the Expiration Date (including
          the right to waive the ineligibility of any Holder who seeks to tender
          Old Notes in the Offer).  In the case of those conditions of the Offer
          that are  dependent  upon the  receipt of  government  approvals,  the
          Company reserves the absolute right to waive such conditions before or
          after the Expiration Date.

          (3) The third to last sentence of the second  paragraph under "Item 8.
     No  Conditional  Tenders" on page 14 of the Letter of Transmittal is hereby
     amended and restated in its entirety as follows:

          The  interpretation of the terms and conditions of the Offer as to any
          particular  Old  Notes  either  before or after  the  Expiration  Date
          (including the Letter of Transmittal and the instructions  thereto) by
          the Company shall be final and binding on all parties participating in
          the  Offer,  subject  to  such  Offer  participant's   disputing  such
          interpretation in a court of competent jurisdiction.

          (4) The third sentence of the first paragraph on page 18 of the Letter
     of Transmittal is hereby amended and restated in its entirety as follows:

          All questions as to the validity, form and eligibility (including time
          of receipt) of such notices will be determined  by the Company,  whose
          determination shall be final and binding on all parties  participating
          in the  Offer,  subject  to such Offer  participant's  disputing  such
          determination in a court of competent jurisdiction.

          (5) The first sentence of the final paragraph of "Item 10.  Withdrawal
     of Tenders" on page 15 of the Letter of  Transmittal  is hereby and amended
     and restated in its entirety as follows:

          All questions as to form and validity  (including  time of receipt) of
          any  delivery  or  revocation  of a tender will be  determined  by the
          Company, in its sole discretion, which determination will be final and
          binding on all  parties  participating  in the Offer,  subject to such
          Offer  participant's  disputing  such  determination  in  a  court  of
          competent jurisdiction.



                                       7


SIGNATURE

     After due inquiry  and to the best of my  knowledge  and belief,  I certify
that the information set forth in this statement is true, complete and correct.

Dated:  July 31, 2006                     INTEGRA LIFESCIENCES HOLDINGS
                                          CORPORATION




                                          By: /s/ MAUREEN B. BELLANTONI
                                              --------------------------------
                                              Name:  Maureen B. Bellantoni
                                              Title: Executive Vice President
                                                     and Chief Financial Officer


                                       8


EXHIBIT INDEX

EXHIBIT
NUMBER      DESCRIPTION
--------    ------------

(a)(1)(i)   Offer to Exchange, dated July 17, 2006.*

(a)(1)(ii)  Letter of Transmittal.*

(a)(1)(iii) Notice of Guaranteed Delivery.*

(a)(1)(iv)  Letter  to  Brokers,  Dealers, Commercial Banks, Trust Companies and
            Other Nominees.*

(a)(1)(v)   Letter to  Clients  for  use  by Brokers, Dealers, Commercial Banks,
            Trust Companies and Other Nominees.*

(a)(1)(vi)  Supplement to Offer to Exchange, dated July 31, 2006.

(a)(5)(i)   Press Release, dated July 17, 2006.*

(a)(5)(ii)  Press Release, dated July 31, 2006.


* Previously filed.



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