GENTIUM
S.p.A.
PIAZZA
XX
SETTEMBRE 2
22079
VILLA GUARDIA (COMO)
ITALY
+39
031
385111
424B3
Filed
on
05/05/2006
File
Number 333-130796
Filed
pursuant to Rule No. 424(b)(3)
File
Number: 333-130796
GENTIUM
S.P.A.
PROSPECTUS
SUPPLEMENT NO. 2
DATED
MAY 5, 2006
TO
PROSPECTUS DATED
JANUARY
30, 2006
This
Prospectus Supplement No. 2 supplements information contained in our prospectus
dated January 30, 2006, as amended and supplemented from time to time (the
“Gentium Prospectus”). The information in this Supplement No. 2 supplements,
modifies and supersedes some of the information contained in the Gentium
Prospectus.
The
purpose of this Prospectus Supplement No. 2 is to inform you that effective
May
16, 2006, our American Depositary Shares (ADSs) will be listed for trading
on
The NASDAQ National Market System under the symbol GENT. Our ADSs will continue
to trade on the American Stock Exchange until they are delisted from the
American Stock Exchange after the market closes on May 15, 2006.
You
should read this Prospectus Supplement No. 2 in conjunction with the Gentium
Prospectus. This Prospectus Supplement No. 2 is not complete without, and may
not be delivered or utilized except in connection with, the Gentium Prospectus
including any amendments or supplements thereto.
Neither
the Securities and Exchange Commission nor any state securities commission
has
approved or disapproved of these securities or passed upon the adequacy or
accuracy of this prospectus. Any representation to the contrary is a criminal
offense.